The Long-term Efficacy of Domiciliary Noninvasive Positive-Pressure Ventilation in Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomized Controlled Trials

다국어 초록 (Multilingual Abstract)

Background: We evaluated the long-term effects of domiciliary noninvasive positive-pressure ventilation (NIPPV) usedto treat patients with chronic obstructive pulmonary disease (COPD).
Methods: Databases were searched to identify randomized controlled trials of COPD with NIPPV for longer than 1 year.
Mortality rates were the primary outcome in this meta-analysis. The eight trials included in this study comprised datafrom 913 patients.
Results: The mortality rates for the NIPPV and control groups were 29% (118/414) and 36% (151/419), suggesting astatistically significant difference (risk ratio [RR], 0.79; 95% confidence interval [CI], 0.65–0.95). Mortality rates werereduced with NIPPV in four trials that included stable COPD patients. There was no difference in admission, acuteexacerbation and quality of life between the NIPPV and control groups. There was no significant difference in withdrawalrates between the two groups (RR, 0.99; 95% CI, 0.72–1.36; p=0.94).
Conclusion: Maintaining long-term nocturnal NIPPV for more than 1 year, especially in patients with stable COPD,decreased the mortality rate, without increasing the withdrawal rate compared with long-term oxygen treatment.

참고문헌 (Reference)

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