발레운동과 올리브 잎 추출물 섭취가 중, 노년여성의 항산화 및 면역기능에 미치는 영향 = The Effects of Ballet Exercise and Supplement Olive Leaf Standardized on SOD, Adiponectin and Inflammatory Factors Middle and Old Aged Women

국문 초록 (Abstract)

본 연구는 발레운동과 올리브 잎 추출물(Olive leaf Standardized)섭취에 따른 항산화효소(SOD), 지방세포단 백질(Adiponectin)과 염증반응지표(IL-6, TNF-α)에 미치는 영향을 규명하여, 중·노년기의 여성의 건강증진에 활용할 수 있는 자료를 제공하고자 하였다. 중·노년(45~70세)여성 45명을 네 집단(발레운동집단15명, 섭취집단10명, 복합처치집단15명, 통제집단5명)으로 구성하여 운동강도 50~70%인 발레운동프로그램에 8주간 참여시킨 후 혈액채취는 실험 전·후로 실시하였다. 항산화효소(SOD), 지방세포단백질(Adiponectin), 인터루킨 -6(IL-6) 그리고 종양괴사인자(TNF-α)측정은 효소면역법(ELISA)를 이용하여 측정하였다. 본 연구의 결과 항산 화효소(SOD)와 지방세포단백질(Adiponectin)의 변화는 운동군과, 섭취군에서 증가하는 경향을 보였으며, 복합처치군에서는 통계적으로 유의하게 증가하는 경향을 보였다. 또한, 인터루킨-6(IL-6), 종양괴사인자(TNF-α)는 모든 실험군에서 감소하는 경향을 보였으며, 특히 운동군에서 통계적으로 유의하게 감소하는 경향을 보였다. 결과적으로 발레운동과 올리브 잎 추출물(Olive leaf Standardized)섭취에 따른 복합처치가 항산화작용의 효과와 더불어 노화예방 및 면역기능 향상에 도움을 줄 수 있을 것으로 사료된다.

다국어 초록 (Multilingual Abstract)

The objective of this study was to investigate the effects of Ballet exercise program and Olive leaf Standardized supplement on Super Oxide Dismutase(SOD), Adiponectin and inflammatory factor in middle and old aged women. The subjects middle and old aged(45~70) 45 women and they were four groups(Ballet exercise Gymnastics Group :15 Supplement group :10, Complex group :15, Control group :5) and participated intensity HRmax 50~70% of Ballet exercise Gymnastics program for 8 weeks training. Blood sampling were performed before and after. The SOD, Adiponectin, IL-6, TNF-α in the blood were analyzed by the ELISA. In This study result, The SOD and Adiponectin were increased to Ballet exercise Gymnastics Group, Supplement group and significant increased Complex group. In addition, The IL-6, TNF-α were decreased significantly in the all experiment group. but Ballet exercise Gymnastics Group was significant difference in the all experiment groups. In conclusion, the complex treatment effects of Ballet exercise Gymnastics program and Olive leaf Standardized supplement protect the effects of anti-oxidation, anti-aging, immunity.

참고문헌 (Reference)

1 권유찬, "유산소와 근저항의 복합트레이닝이 비만 청소년의 림프구 및 TNF-α 농도에 미치는 영향" 한국체육학회 42 (42): 335-346, 2003

2 천금석, "운동형태가 비만여고생의 신체구성, 인슐린민감성, 염증유발인자 및 Leptin에 미치는 영향" 경상대학교 대학원 2010

3 최남영, "올리브 잎 분획물의 항산화기능과 아질산염 소거능력 평가" 한국식품과학회 40 (40): 257-264, 2008

4 정성림, "순환 운동과 유산소 운동이 비만 중년여성의 대사성증후군 위험 인자, 동맥경화 지수 및 혈관 염증지표 변화에 미치는 영향" 창원대학교 대학원 2007

5 정성림, "순환 운동과 유산소 운동이 비만 중년여성의 대사성증후군 위험 인자, 동맥경화 지수 및 혈관 염증지표 변화에 미치는 영향" 창원대학교 대학원 2007

6 신윤정, "비만 여성의 10주간 댄스스포츠 프로그램 수행 후 혈중 대사기질, 호르몬 및 사이토카인 농도의 변화" 한국체육학회 43 (43): 467-480, 2004

7 조완주, "복합운동프로그램이 비만중년여성의 건강관련체력과 혈액성분 및 염증지표에 미치는 영향" 조선대학교 대학원 2009

8 노연경, "발레의 바(Bar)연습을 위한 교수 방법 연구" 이화여자대학교 대학원 2000

9 朴仁子, "발레의 强度別 訓練이 精神建康과 스트레스 호르몬에 미치는 影響" 한양대학교 대학원 1998

10 안나파스케브스카, "발레 예술과 과학" 도서출판금광 2000

11 차창룡, "면역학" 서울대학교출판부 1994

12 Maeda, K., "cDNA cloning and expression of a novel adipose specific collagen-like factor" 221 : 286-289, 1996

13 Shephard, R. J., "What is the optimal type of physical activity to enhance health?" 31 (31): 277-284, 1997

14 Diez, J. J., "The role of the novel adipocyte-derived hormone adiponectin in human disease" 148 : 293-300, 2003

15 Johnson, F., "Superoxide dismutase and their impact upon human health" 26 (26): 340-352, 2005

16 Ryan, A. S., "Ruantitative changees in phenolic content during physiological development of the olive oleaeuropaea cultivar Hardy's Mammoth" 51 (51): 2532-25383, 2003

17 Graham, T. E., "Retinol-binding protein and insulin resistancein lean,obese, and diabetic subjects" 354 : 2552-2563, 2006

18 Yatagai, T., "Relationship between exercise training-induced increase in insulin sensitivity and adiponectinemiain healthy men" 50 : 233-238, 2003

19 Pischon, N., "Regulation of collagen deposition and lysyl oxidase by tumor necrosis factor-alpha in osteoblasts" 279 (279): 30060-30065, 2004

20 Mattusch, F., "Reduction of the plasma concentration of C-reactive protein following nine months of endurance training" 21 (21): 21-24, 2000

21 Ziccardi, P., "Reduction of inflammatory cytokine concentration and improvementofendothelialfunctions in obese women after weight loss over one year" 105 : 804-809, 2002

22 Kim, S. M., "Pseudocohnilembus persalinus (Ciliophora: Scuticociitida) is an additional species causing scuticociliatosis in olive flounder Paralichthys olivaceus" 62 (62): 239-244, 2004

23 Yoon, T. J., "Prophylactic effect of Korean mistletoe extract on tumor metastasis is mediated by enhancement of NK cell activity" 20 : 163-172, 1998

24 Kern, M. A., "Precision cut tissue slices of the liver as morphological tool for investigation of apoptosis" 19 (19): 423-431, 2005

25 Wilmore, J. H., "Physiology of sport and exercise" Champaign 1999

26 Baillargeon, J., "Obesity and survival in a cohort of predominantly Hispanic children with acute lymphoblastic leukemia" 28 (28): 575-578, 2006

27 Boguszewska, A., "Melatonin and its biological significance" 17 (17): 523-527, 2004

28 Tvede, N., "Mechanisms of B-lymphocyte suppression induced by acute physical exercise" 30 (30): 169-173, 1989

29 Yoon, T. J., "Lectins isolated from Korean mistletoe induce apoptosis in tumor cells" 136 : 33-40, 1999

30 Inbar, J., "Lectins and biocontrol" 17 : 1-20, 1997

31 Jenkin, s. R. R., "Introduction : Oxidant stress, aging and exercise" 25 (25): 210-212, 1993

32 Yoon, T. J., "Inhibitory effect of Korean mistletoe extract on tumor angiogenesis of haematogenous andnon-haematogenous cells" 97 (97): 83-91, 1995

33 Bechoua, S., "Influence of very low dietary intake of marine oil on some functional aspects of immune cells in healthy elderly people" 89 (89): 523-531, 2003

34 Jankord, R., "Influence of physical activity on serum IL-6 and IL-10 levels in healthy older men" 36 (36): 960-964, 2004

35 Halliwell, B., "Free radicals in biology an dmedicine" Oxford Clarendon Press 1989

36 Chin, T., "Experimental analysis of silicone leakage" 76 (76): 109-112, 2009

37 Powers, S. K., "Exercise training-induced alterations in skeletal muscle antioxidant capacity : abriefreview" 31 (31): 987-997, 1999

38 Kriketos, A. D., "Exercise increases adiponectin levels and insulin sensitivity in humans" 27 : 629-630, 2004

39 Monzillo, L. U., "Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance" 11 : 1048-1054, 2003

40 Yokoyama, H., "Effect of aerobic exercise on plasma adiponect in levels and insulin resistance in type2 diabetes" 27 : 1756-1758, 2004

41 Cvjetićanin, T., "Dried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in mice" 103 (103): 1413-1424, 2010

42 Grant, M. M., "Dose-dependent modulation of the T cell proteome by ascorbic acid" 97 (97): 19-26, 2007

43 Tauler, P., "Differential response of lymphocytes and neutrophils to high intensity physical activity and to vitamin C diet supplementation" 37 (37): 931-938, 2003

44 Tauler, P., "Diet supplementation with vitamin E, vitamin C and beta-carotenecocktail enhances basal neutrophil antioxidant enzymes inathletes" 443 (443): 791-797, 2002

45 Bruun, J. M., "Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects" 290 (290): 961-967, 2006

46 Yoon, T. J., "Cellular and humoral adjuvant activity of lectins isolated from Korean mistletoe (Viscuma lbum colaratum)" 1 (1): 881-889, 2001

47 Hara, T., "Body composition isrelated to increasein plasma adiponectin level srather than trining in young obesemen" 94 : 520-526, 2005

48 Ullum, H., "Bicycle exercise enhances plasma IL-6 but does not change IL-1α, IL-1β, IL-6, or TNF-α pre-mRNA in BMNC" 77 : 93-97, 1994

49 Ji, L. L., "Antioxidant enzyme systems in rat liver and skeletal muscle" 263 : 150-160, 1988

50 Ji, L. L., "Antioxidant enzyme response to exercise and aging" 25 (25): 225-231, 1993

51 Nieman, D. C., "Age-related changes in specific IgE antibody production" 68 (68): 520-524, 1992

52 Kohut, M. L., "Aerobic exercise but not flexibility/resistance exercise reduces serum IL-1,CRP and IL-6 independent of beta-blockers, BMI and psychological factors In older adults" 24 : 252-265, 2006

53 Chandran, M., "Adiponectin: more than just another fat cell hormone?" 26 (26): 442-2450, 2003

54 Ryan, A. S., "Adiponectin levelsdo not change with moderate dietary induced weight loss and exercise in obese postmenopausal women" 279 : 1066-1071, 2003

55 Hulver, M. W., "Adiponectin is not altered with exercise training despite enhanced insulinaction" 283 : E861-E865, 2002

56 Gable, D. R., "Adiponectin and gene variants as risk factors for insulin resistance. the metabolic and cardiovascular disease" 188 : 231-244, 2006

57 Hu, E., "AdipoQ is a novel adipose-specific gene dysergulated in obesity" 271 (271): 10697-10703, 1996