구강작열감증후군과 구강 내 Helicobacter pylori의 상호관련성 = Relationship between burning mouth syndrome and Helicobacter pylori in the oral cavity

다국어 초록 (Multilingual Abstract)

Helicobacter pylori(H. pylori) is bacterial infection, with more than half of the world population infected and relates to many oral disease such oral lichen planus, recurrent aphthous ulceration, periodontal disease and halitosis and so on. Burning mouth syndrome(BMS) is defined as a burning sensation of the oral mucosa, lips, and/or tongue, in the absence of specific oral lesions. The etiology of BMS is suggested local, systemic and psychological factors and researchs related BMS and to infection of H. pyloir in the oral cavity are few.
The purpose of this study was to evaluate relationship between burning mouth syndrome and H. pylori in the oral cavity. We recruited 21 subjects with burning mouth syndrome and 21 subjects as control group. Samples in the oral cavity were taken area of buccal mucosa, dorsum of the tongue and saliva. We analysed samples by nested polymerase chain reaction(PCR).

The results were as follows :

1. Among 21 patients with burning mouth sydrome and 21 subjects of control group, 6(29%) and 3(14%) were positive respectively(P>0.05).

2. In detection rate of H. pylori in area taken sample, 3(14%), 2(10%) and 4(19%) were positive in buccal mucosa, dorsum of the tongue and saliva of patient and 2(10%) and 1(5%) were positive in dorsum of the tongue and saliva of control group(P>0.05).

Conclusively, we can guess that H. pylori in the oral cavity is not related with burning mouth syndrome.

목차 (Table of Contents)

• 목 차
• ABSTRACT...................................................................................................................... ⅳ
• Ⅰ. 서론 ............................................................................................................................... 1
• Ⅱ. 연구대상 및 연구방법.............................................................................. 2
• A. 연구대상
• B. 연구방법
• 1. Helicobacter pylori Nested PCR
• a. 샘플 채취
• b. DNA 추출
• c. Nested PCR 분석
• d. 전기영동
• 2. 통계처리
• Ⅲ. 연구결과...................................................................................................................... 5
• A. 구강작열감증후군 환자군과 대조군에서 H. pylori의 발현율
• B. 샘플채취부위에 따른 H. pylori의 발현율
• Ⅳ. 총괄 및 고찰......................................................................................................... 7
• Ⅴ. 결론 ........................................................................................................................... 9
• 참고문헌 ...................................................................................................................................... 10