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Kim, I.S.,Kim, T.H.,Yang, P.S.,Uhm, J.S.,Joung, B.,Lee, M.H.,Pak, H.N. Japanese College of Cardiology 2017 Journal of cardiology Vol.69 No.1
<P>Conclusions: Higher E(min)ECVpre was independently associated with clinical recurrence and earlier recurrence timing of AF after catheter ablation among patients with AAD-resistant L-PeAF. Catheter ablation for L-PeAF significantly reduces EminECV. (C) 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</P>
Park, J.K.,Lee, J.Y.,Yang, P.S.,Kim, T.H.,Shin, E.,Park, J.,Uhm, J.S.,Joung, B.,Lee, M.H.,Pak, H.N. Japanese College of Cardiology 2017 Journal of cardiology Vol.69 No.3
<P>Conclusions: Despite a relatively high recurrence rate after RFCA for L-PeAF, patients with a shorter AF duration and smaller LA size showed a more favorable outcome. The rs2106216 polymorphism (ZFHX3) was independently associated with being good responders to RFCA for L-PeAF, especially with AF duration 12-65 months. (C) 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</P>
Park, J.,Lee, S.H.,Lee, J.S.,Park, J.H.,Joung, B.,Lee, M.H.,Chang, B.C.,Pak, H.N. Japanese College of Cardiology 2017 Journal of cardiology Vol.69 No.1
<P>Conclusions: A lower ANP atrial tissue expression and amyloid deposits were correlated with a high pre-operative hemodynamic loading, and those patients had a paradoxically lower AF recurrence after relief of the hemodynamic burden by concomitant maze and mitral valve surgery. (C) 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</P>
Cho, J.Y.,Kim, K.H.,Kim, J.Y.,Sim, D.S.,Yoon, H.J.,Yoon, N.S.,Hong, Y.J.,Park, H.W.,Kim, J.H.,Ahn, Y.,Jeong, M.H.,Cho, J.G.,Park, J.C. Japanese College of Cardiology 2016 Journal of cardiology Vol.68 No.5
<P>Conclusions: The improvement of LV systolic function was the only independent predictor of reversible TR. Appropriate medical therapy including management for heart failure should be considered before performing surgery in patients with severe functional TR and AF, especially in patients with LV dysfunction. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</P>
Kim, T.H.,Shim, C.Y.,Park, J.H.,Nam, C.M.,Uhm, J.S.,Joung, B.,Lee, M.H.,Pak, H.N. Japanese College of Cardiology 2016 Journal of cardiology Vol.68 No.2
<P>Background: Although the degree of electroanatomical remodeling of the left atrium (LA) is influenced by left ventricular (LV) diastolic function, clinical implications of estimated LV filling pressure (E/Em) are limited in patients with atrial fibrillation (AF). We hypothesized that increased E/Em is related to an advanced LA remodeling, a high CHA(2)DS(2)-VASc score, and the presence of stroke or transient ischemic attack (TIA) in patients with paroxysmal AF. Methods: We included 1098 patients with paroxysmal AF (male 74.5%, 57.6 +/- 11.3 years old) who underwent AF catheter ablation. We compared E/Em to clinical parameters, echocardiography, and three-dimensional -computed tomography findings. Results: The E/Em > 15 group (n = 98) was older (p < 0.001) and had more females (p < 0.001), greater LA volume index (p < 0.001), higher CHA(2)DS(2)-VASc score (p < 0.001), and stroke/TIA prevalence (p = 0.001) than groups with an E/Em of 8-15 (n = 676) or <8 (n = 324). An E/Em was independently associated with the presence of stroke/TIA (OR 1.638, 95% CI 1.050-2.554, p = 0.030) after adjusting for age, sex, body surface area, LA volume index, and LA appendage volume index. Conclusions: In patients with paroxysmal AF, the elevated LV filling pressure estimated by E/Em is independently associated with the presence of stroke or TIA. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</P>
for the Korea Acute Myocardial Infarction Registry Investigators,Park, H.,Kim, H.K.,Jeong, M.H.,Cho, J.Y.,Lee, K.H.,Sim, D.S.,Yoon, N.S.,Yoon, H.J.,Hong, Y.J.,Kim, K.H.,Park, H.W.,Kim, J.H.,Ahn, Y.,Ch Japanese College of Cardiology 2017 Journal of cardiology Vol.69 No.1
<P>Conclusions: In latecomers with STEMI, RAS inhibition improved long-term clinical outcomes after a successful PCI, even in patients with low risk who had relatively preserved LVEF. (C) 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</P>
Benefit of statin therapy in patients with coronary spasm-induced acute myocardial infarction
Other Korea Acute Myocardial Infarction Registry Investigators,Piao, Z.H.,Jeong, M.H.,Li, Y.,Jin, L.,Kim, H.K.,Park, K.H.,Sim, D.S.,Kim, K.H.,Hong, Y.J.,Park, H.,Kim, J.H.,Ahn, Y.,Cho, J.G.,Park, J.C. Japanese College of Cardiology 2016 Journal of cardiology Vol.68 No.1
<P>Background: Coronary artery spasm is associated with vascular smooth muscle hyper-reactivity. Statins suppress coronary spasm by inhibiting the vascular smooth muscle contraction. However, it is unclear whether statin therapy benefits patients with coronary spasm-induced acute myocardial infarction (AMI). Methods and results: We analyzed 501 (median age 57 years; male/female, 346/155) patients with coronary spasm-induced AMI with nonobstructive coronary arteries (stenosis severity <50%) from the Korea AMI Registry between November 2005 and October 2013. They were divided into two groups according to statin prescription at discharge (statin group n = 292; nonstatin group n = 209). The primary endpoint was the composite of 12-month major adverse cardiac events, including all causes of death, non-fatal myocardial infarction, and target vessel revascularization. The primary endpoint occurred in 17 patients during 12 months of follow-up. Statin therapy significantly reduced the risk of the composite primary endpoint [adjusted hazard ratio (HR): 0.30; 95% confidence interval (CI): 0.09-0.97; p = 0.045]. Statin therapy reduced the risk of myocardial infarction (HR: 0.19; 95% CI: 0.04-0.93; p = 0.040). However, we found no significant difference in the risk of the composite of all-cause death. Conclusion: Statin therapy in patients with coronary spasm-induced AMI with nonobstructive coronary arteries was associated with improved clinical outcome, which was predominantly accounted for by reducing the incidence of myocardial infarction. (C) 2016 Published by Elsevier Ltd on behalf of Japanese College of Cardiology.</P>
Lee,, S.Y.,Shin, D.H.,Shehata, I.,Kim, J.S.,Kim, B.K.,Ko, Y.G.,Choi, D.,Jang, Y.,Hong, M.K. Japanese College of Cardiology 2016 Journal of cardiology Vol.68 No.4
<P>Background: The assessment of fractional flow reserve (FFR) in coronary lesions determines the strategy of percutaneous coronary intervention. However, the association between FFR and characteristics of the underlying coronary plaque has not been sufficiently investigated. Methods: A total of 110 coronary lesions in 106 patients were evaluated using both FFR and optical coherence tomography (OCT). Coronary plaques were classified into fibrous, fibrocalcific, or fibroatheroma according to 00' evaluation at the site of minimal lumen area. Plaque microstructures such as cap thickness, macrophage accumulation, intimal vasculature, or cholesterol crystals were also evaluated. Results: Lesions with FFR <= 0.8 showed a higher frequency of fibroatheroma, macrophage accumulation, and cholesterol crystals when compared to those with FFR > 0.8. The angle of lipid was wider in lesions with FFR <= 0.8 (145.1 +/- 63.0 degrees vs. 120.7 +/- 48.9 degrees, p = 0.047), and the longitudinal length was longer in those with FFR <= 0.8 (4.2 +/- 2.8 mm vs. 2.5 +/- 2.9 mm, p = 0.007). However, multiple linear regression analysis revealed that the morphological characteristics of plaques assessed by OCT were not independently associated with FFR. Minimal lumen area [coefficient, 0.035; 95% confidence interval (CI), 0.022-0.048; p < 0.001] and area stenosis (coefficient, -0.003; 95% CI, 0.005 to -0.001; p = 0.001) assessed by OCT significantly correlated with FFR. Conclusion: The morphological characteristics of coronary plaque derived from OCT are not directly related to FFR. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</P>
other Korea Acute Myocardial Infarction Registry Investigators,Kim, H.K.,Jeong, M.H.,Ahn, Y.,Chae, S.C.,Kim, Y.J.,Hur, S.H.,Seong, I.W.,Hong, T.J.,Choi, D.H.,Cho, M.C.,Kim, C.J.,Seung, K.B.,Jang, Y.S. Japanese College of Cardiology 2017 Journal of cardiology Vol.69 No.1
<P>Conclusion: Despite improvements in door-to-balloon time, no parallel reductions in mortality rate and total ischemic time were observed. Total ischemic time was associated with mortality. The present study suggests that additional efforts are needed to shorten total ischemic time including patient and pre hospital systemic delay for better prognosis after primary PCI. (C) 2016 Published by Elsevier Ltd on behalf of Japanese College of Cardiology.</P>
Sim, D.S.,Jeong, M.H.,Cha, K.R.,Park, S.H.,Park, J.O.,Shin, Y.M.,Shin, H.,Hong, Y.J.,Ahn, Y.,Schwartz, R.S.,Kang, J.C. Japanese College of Cardiology 2012 Journal of cardiology Vol.60 No.6
Background: Chronic total occlusion (CTO) remains a challenge in interventional cardiology. We investigated the feasibility and reliability of copper wire stents and levo-polylactic acid (l-PLA) as a means of CTO induction in a porcine model. Methods and results: In one group of 20 swine, copper stents were crimped on a 3.0mm angioplasty balloon and inserted into the mid-left anterior descending coronary artery (LAD). In the other group of 20 swine, l-PLA was wrapped on a guidewire and pushed into the distal LAD with a 3.0mm balloon catheter to induce embolization. Of 20 swine which underwent copper stent implantation, 13 died of stent thrombosis. In the remaining 7 swine, total or near total occlusion with collateral circulation was observed at 5weeks. Of 20 swine which underwent l-PLA embolization, 4 died of ventricular fibrillation during or shortly after the procedure. Serial histopathologic studies showed complete absorption of the polymer with replacement by fibrotic tissue approximately 4weeks following the polymer implantation. Conclusions: CTO could be reliably induced in porcine coronary arteries by copper stents and l-PLA. These models may support investigation of new percutaneous devices to facilitate CTO interventions.