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- 저자 : Zhu Weiwen (검색결과 2 건)
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A Bayesian optimal design for degradation tests based on the inverse Gaussian process
Weiwen Peng,Yu Liu,Yanfeng Li,Shun-Peng Zhu,Hong-Zhong Huang 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.10
The inverse Gaussian process is recently introduced as an attractive and flexible stochastic process for degradation modeling. This processhas been demonstrated as a valuable complement for models that are developed on the basis of the Wiener and gamma processes. We investigate the optimal design of the degradation tests on the basis of the inverse Gaussian process. In addition to an optimal designwith pre-estimated planning values of model parameters, we also address the issue of uncertainty in the planning values by using theBayesian method. An average pre-posterior variance of reliability is used as the optimization criterion. A trade-off between sample sizeand number of degradation observations is investigated in the degradation test planning. The effects of priors on the optimal designs andon the value of prior information are also investigated and quantified. The degradation test planning of a GaAs Laser device is performedto demonstrate the proposed method.
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AuNP-Loaded Electrospinning Membrane Cooperated with CDs for Periodontal Tissue Engineering
Wang Jie,Zhang Hang,Wang Yan,Liu Xiang,Zhu Weiwen,Jiang Fei,Li Size,Liu Laikui 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.7
BACKGROUND: Guided bone regeneration (GBR) is commonly used to regenerate periodontal tissue. However, the bone inductivity and antibacterial properties of the GBR membranes currently in use are severely limited. This issue can be resolved by loading growth factors and antibiotics. Bioactive substitutes, such as Au nanoparticles (AuNPs) and carbon quantum dots (CDs), were proposed to prevent the denaturation of osteogenic growth factors and the induction of antibacterial drug resistance. METHODS: Ornidazole was initially used as the raw material to prepare the CDs, followed by the incorporation of an optimal ratio of nanoparticles to produce the electrospun membrane doped with AuNPs and novel traceable antibacterial CDs. The morphology of the membrane was characterized. The adhesion, proliferation, and osteogenic differentiation of cells on the membrane were evaluated in vitro. The antimicrobial characteristics of the membrane were also investigated. The electrospun membrane was implanted into a rat skull defect model in vivo to investigate its osteogenic potential. RESULTS: The blending of nanomaterials did not affect the micro morphology of the fiber, resulting in enhanced mechanical properties. Membranes doped with AuNPs and CDs exhibited excellent biocompatibility, increased ALP activity, improved calcified nodules, and increased expression of osteogenic-associated proteins, in addition to pronounced antibacterial effects. The membrane also demonstrated excellent osteogenic characteristics in rat models. CONCLUSION: The synergistic effect of loaded AuNPs electrospun fiber membrane with CDs can promote periodontal bone regeneration and exert antibacterial activity.
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