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Teik Hin Tan,Zanariah Hussein,Fathinul Fikri Ahmad Saad,Ibrahim Lutfi Shuaib 대한핵의학회 2015 핵의학 분자영상 Vol.49 No.2
Purpose To evaluate the diagnostic performance of 68Ga- DOTATATE 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT), 18F-FDGPET/CTand 131I-MIBG scintigraphy in themapping of metastatic pheochromocytoma and paraganglioma. Materials and Methods Seventeen patients (male=8, female=9; age range, 13–68 years) with clinically proven or suspicious metastatic pheochromocytoma or paraganglioma were included in this prospective study. Twelve patients underwent all three modalities, whereas five patients underwent 68Ga-DOTATATE and 131I-MIBG without 18FFDG. A composite reference standard derived from anatomical and functional imaging findings, along with histopathological information, was used to validate the findings. Results were analysed on a per-patient and on per-lesion basis. Sensitivity and accuracy were assessed using McNemar’s test. Results On a per-patient basis, 14/17 patients were detected in 68Ga-DOTATATE, 7/17 patients in 131I-MIBG, and 10/12 patients in 18F-FDG. The sensitivity and accuracy of 68Ga- DOTATATE, 131I-MIBG and 18F-FDG were (93.3 %, 94.1 %), (46.7 %, 52.9 %) and (90.9 %, 91.7 %) respectively. On a per-lesion basis, an overall of 472 positive lesions were detected; of which 432/472 were identified by 68Ga-DOTATA TE, 74/472 by 131I-MIBG, and 154/300 (patient, n=12) by 18F-FDG. The sensitivity and accuracy of 68Ga-DOTATATE, 131I-MIBG and 18F-FDG were (91.5 %, 92.6 % p<0.0001), (15.7 %, 26.0 % p<0.0001) and (51.3 %, 57.8 % p<0.0001) respectively. Discordant lesions were demonstrated on 68Ga- DOTATATE, 131I-MIBG and 18F-FDG. Conclusions Ga-DOTATATE PET/CT shows high diagnostic accuracy than 131I-MIBG scintigraphy and 18F-FDG PET/ CT in mapping metastatic pheochromocytoma and paraganglioma.
Dual Thyroid Ectopia with Graves' Disease: a Case Report and a Review of the Literature
Tan, Teik Hin,Lee, Boon Nang,Hassan, Siti Zarina Amir,Ch'ng, Ewe Seng,Hussein, Zanariah The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.4
Ectopic thyroid or thyroid ectopia is a rare developmental anomaly with the prevalence of 1 per 100,000-300,000 population. Even rarer, such an anomaly manifests as dual thyroid ectopia. To our best knowledge, only one case has been reported on dual thyroid ectopia with Graves' disease in the English literature. We present here a case of dual thyroid ectopia complicated by Graves' disease, whereby the diagnosis was rendered through judicious use of various diagnostic modalities coupled with a close clinical follow-up. In this case, therapeutic consideration should be personalized with proper informed consent of the patient.