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- 저자 : Yuki Kagawa (검색결과 3 건)
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Yuki Kagawa,Kazuhiko Noda,Tadashi Shinohara,Hachiro Imai 한국표면공학회 2010 한국표면공학회 학술발표회 초록집 Vol.2010 No.11
Analysis of concentration of chloride ion in crevice corrosion was done on type 304 stainless steel by immersion of the specimen in 0.5 ㏖/l NaCl solutions and measured using galvanostatic measurement in occluded cell. The anodic reaction in crevice corrosion could be estimated as the changing the concentration of chloride ion by using occluded cell. The condense of the chloride ion was derived by keeping the neutrality in the crevice area. The results show that chloride ion concentrations in crevice during the crevice corrosion growth. This proves that the use of Ag / AgCl electrode can be applied for chloride ion measurement in crevice corrosion.
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Atmospheric Corrosion Behavior of the Pure Zirconium
Ayami Kameda,Yuki Kagawa,Ayumu Yokota,Youhei Hirohata,Kazuhiko Noda 한국표면공학회 2010 한국표면공학회 학술발표회 초록집 Vol.2010 No.11
The zircalloy improved the corrosion resistance and the materials strength, largely is used for a fuel aggregate member, a pressure pipe, and the fuel coating pipes of the nuclear reactor. The estimation of the reaction characteristics of pure zirconium is important in order to investigate the application in actual using. The pure zirconium was examined by the polarization curves measurement in solution environment and the surface potential distribution measurement to evaluate the stability of the passive film on zirconium as the fundamental data. A surface potential measurement device with non-contact probe is applied to measure the potential of the pure zirconium. The corrosion behavior of the pure zirconium surface is also investigated by using the surface potential date. The surface potential distribution of pure zirconium shows a good corrosion resistance in the atmospheric condition.
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Gao Botao,Sakaguchi Katsuhisa,Ogawa Tetsuya,Kagawa Yuki,Kubo Hirotsugu,Shimizu Tatsuya 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.2
BACKGROUND: Ballooned hepatocytes (BH) are a key histological hallmark of nonalcoholic steatohepatitis (NASH), yet their consequences for liver-specific functions are unknown. METHODS: In our previous study, an experimental model of human induced-BHs (iBH) has been successfully developed based on cell sheet technology. This study aimed to determine the functions of iBHs in the primary human hepatocyte/normal human dermal fibroblast (PHH/NHDF) co-culture cell sheets. Normal hepatocytes in the PHH/3T3-J2 co-culture cell sheets were set as a control, since 3T3-J2 murine embryonic fibroblasts have exhibited previously long term maintenance of PHH functions. RESULTS: It was found that, albumin secretion was not affected in iBHs, but urea synthesis as well as cytochrome P450 enzyme (CYP) activities including CYP1A2 and CYP3A4, were significantly reduced in iBHs. Besides, loss of bile canaliculi was observed in iBHs. These findings are consistent with clinical studies of human NASH. In addition, PHH/NHDF cell sheets demonstrated two fold higher TGF-β1 secretion compared with PHH/3T3-J2 cell sheets. Furthermore, treatment with a TGF-β inhibitor and a semi-synthetic bile acid analogue (obeticholic acid, phase 3 trial of NASH therapy) ameliorated the histological appearance of established iBHs. CONCLUSION: In summary, this study demonstrates the priority of iBHs in recapitulating not only histology but also clinically relevant hepatic dysfunctions in human NASH and suggests TGF-β and bile acid related signal pathway may play important roles in the formation of iBHs. BACKGROUND: Ballooned hepatocytes (BH) are a key histological hallmark of nonalcoholic steatohepatitis (NASH), yet their consequences for liver-specific functions are unknown. METHODS: In our previous study, an experimental model of human induced-BHs (iBH) has been successfully developed based on cell sheet technology. This study aimed to determine the functions of iBHs in the primary human hepatocyte/normal human dermal fibroblast (PHH/NHDF) co-culture cell sheets. Normal hepatocytes in the PHH/3T3-J2 co-culture cell sheets were set as a control, since 3T3-J2 murine embryonic fibroblasts have exhibited previously long term maintenance of PHH functions. RESULTS: It was found that, albumin secretion was not affected in iBHs, but urea synthesis as well as cytochrome P450 enzyme (CYP) activities including CYP1A2 and CYP3A4, were significantly reduced in iBHs. Besides, loss of bile canaliculi was observed in iBHs. These findings are consistent with clinical studies of human NASH. In addition, PHH/NHDF cell sheets demonstrated two fold higher TGF-β1 secretion compared with PHH/3T3-J2 cell sheets. Furthermore, treatment with a TGF-β inhibitor and a semi-synthetic bile acid analogue (obeticholic acid, phase 3 trial of NASH therapy) ameliorated the histological appearance of established iBHs. CONCLUSION: In summary, this study demonstrates the priority of iBHs in recapitulating not only histology but also clinically relevant hepatic dysfunctions in human NASH and suggests TGF-β and bile acid related signal pathway may play important roles in the formation of iBHs.
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