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A NON-LINEAR APPROACH TO JAPANESE BUSINESS CYCLES
Yasuyuki Nishigaki,Yuichi Ikeda,Mitsuhiko Satake People&Global Business Association 2007 Global Business and Finance Review Vol.12 No.3
A considerable amount of interest has been taken in empirical tests to determine chaos in business cycles after the introduction of the non-linear approach to economics. Amongst the several empirical works on macro-economic time series. Frank. Gencay and Stengos (1988) found the strong non-linearity in the Japanese data. This paper attempts to provide a precise mathematical version of empirical tests on Japanese time series for the presence of low-dimensional deterministic chaos. The "residual diagnostics" which was first presented by Brock(1986) is conducted on the Japanese macro-economic quarterly time series. including the periods of "rapid growth", "two oil crises" and "bubble economy and after bubble depression "(from 1955 to 2000). For the low-dimensional deterministic chaos tests. the correlation integral correlation dimension and BDS statistics are examined Empirical results show that the correlation dimension grew linearly with the embedding dimension and did not saturate at any value. The BDS statistics distribution has a large peak near 0. Based on these results, evidence for chaos in the Japanese quarterly macro-economic time series is weak. and fluctuations are primarily caused by "random noise."
Serum Periplakin as a Potential Biomarker for Urothelial Carcinoma of the Urinary Bladder
Matsumoto, Kazumasa,Ikeda, Masaomi,Matsumoto, Toshihide,Nagashio, Ryo,Nishimori, Takanori,Tomonaga, Takeshi,Nomura, Fumio,Sato, Yuichi,Kitasato, Hidero,Iwamura, Masatsugu Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
The objectives of this study were to examine serum periplakin expression in patients with urothelial carcinoma of the urinary bladder and in normal controls, and to examine relationships with clinicopathological findings. Detection of serum periplakin was performed in 50 patients and 30 normal controls with anti-periplakin antibodies using the automatic dot blot system, and a micro-dot blot array with a 256 solid-pin system. Levels in patients with urothelial carcinoma of the urinary bladder were significantly lower than those in normal controls (0.31 and 5.68, respectively; p<0.0001). The area under the receiver-operator curve level for urothelial carcinoma of the urinary bladder was 0.845. The sensitivity and specificity, using a cut-off point of 4.045, were 83.7% and 73.3%, respectively. In addition, serum periplakin levels were significantly higher in patients with muscle-invasive cancer than in those with nonmuscle-invasive cancer (P = 0.03). In multivariate Cox proportional hazards regression analysis, none of the clinicopathological factors was associated with an increased risk for progression and cancer-specific survival. Examination of the serum periplakin level may play a role as a non-invasive diagnostic modality to aid urine cytology and cystoscopy.
Matsumoto, Kazumasa,Ikeda, Masaomi,Hirayama, Takahiro,Nishi, Morihiro,Fujita, Tetsuo,Hattori, Manabu,Sato, Yuichi,Ohbu, Makoto,Iwam, Masatsugu Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Background: The aim of this study was to evaluate 10 years of false positive urine cytology records, along with follow-up histologic and cytologic data, to determine the significance of suspicious urine cytology findings. Materials and Methods: We retrospectively reviewed records of urine samples harvested between January 2002 and December 2012 from voided and catheterized urine from the bladder. Among the 21,283 urine samples obtained during this period, we located 1,090 eligible false positive findings for patients being evaluated for the purpose of confirming urothelial carcinoma (UC). These findings were divided into three categories: atypical, indeterminate, and suspicious of malignancy. Results: Of the 1,090 samples classified as false positive, 444 (40.7%) were categorized as atypical, 367 (33.7%) as indeterminate, and 279 (25.6%) as suspicious of malignancy. Patients with concomitant UC accounted for 105 (23.6%) of the atypical samples, 147 (40.1%) of the indeterminate samples, and 139 (49.8%) of the suspicious of malignancy samples (p<0.0001). The rate of subsequent diagnosis of UC during a 1-year follow-up period after harvesting of a sample with false positive urine cytology initially diagnosed as benign was significantly higher in the suspicious of malignancy category than in the other categories (p<0.001). The total numbers of UCs were 150 (33.8%) for atypical samples, 213 (58.0%) for indeterminate samples, and 199 (71.3%) for samples categorized as suspicious of malignancy. Conclusions: Urine cytology remains the most specific adjunctive method for the surveillance of UC. We demonstrated the clinical value of dividing false positive urine cytology findings into three categories, and our results may help clinicians better manage patients with suspicious findings.
Tsumura, Hideyasu,Matsumoto, Kazumasa,Ikeda, Masaomi,Yanagita, Kengo,Hirano, Shuhei,Hagiwara, Masahiro,Nagashio, Ryo,Fujita, Tetsuo,Sato, Yuichi,Iwamura, Masatsugu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Background: Uroplakins have been widely investigated as potential markers in patients with bladder cancer because these proteins are specific to the urothelium. However, the role of uroplakin proteins in bladder cancer remains unknown. In this study, preoperative serum levels of uroplakin III were measured in patients with urothelial carcinoma of the urinary bladder and examined for possible association with clinicopathological features and clinical outcomes. Materials and Methods: This study included 52 bladder cancer patients at various stages and 28 healthy controls. Uroplakin III levels were detected in preoperative sera using an automated dot blot system and a micro-dot blot array. Results: There was a significant increase in serum uroplakin III levels in patients with bladder cancer as compared to healthy controls (p<0.05). In addition, serum uroplakin III levels were associated with muscle-invasive status, high grade and lymphovascular invasion (p<0.02). Log-rank tests indicated high serum uroplakin III to be significantly associated with cancer-specific mortality. Conclusions: Determination of serum uroplakin III level could be valuable for identifying patients with biologically aggressive bladder cancer.
High-field Multi-frequency ESR in the S=2 Heisenberg Antiferromagnetic Chain Compound MnCl3(bpy)
Masayuki Hagiwara,Masami Ikeda,Yuichi Idutsu,Shojiro Kimura,Zentaro Honda 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
We report the results of high-field multi-frequency electron spin resonance (ESR) experimentson a powder sample of MnCl3 (bpy) (bpy=2, 2’-bipyridine). This compound is one of the rareexamples of the spin (S) 2 quasi one-dimensional (1D) Heisenberg antiferromagnets (HAFs), andmagnetic properties of tiny single crystal samples were reported previously (G. E. Granroth et al.,Phys. Rev. Lett. 77, 1616 (1996).). In our previous paper on this compound (M. Hagiwara et al.,J. Phys.: Conf. Ser. 400, 032014 (2012).), we reported, for the S=2 1D HAF, good agreementbetween experiment and calculation for the temperature dependence of magnetic susceptibility andthe high-field magnetization process at 1.3 K. In this work, we have observed some high-frequencyresonance modes with zero-field gaps of about 800 GHz that may correspond to antiferromagneticresonance modes with orthorhombic anisotropy in a long-range-ordered phase that emerged at lowtemperatures above the critical field at which the energy gap (Haldane gap) closes. The single-ionanisotropy constant D evaluated from the analysis of these ESR modes is larger than that reportedpreviously.
Zeeshan Sheikh,Nader Hamdan,Yuichi Ikeda,Marc Grynpas,Bernhard Ganss,Michael Glogauer 한국생체재료학회 2017 생체재료학회지 Vol.21 No.2
Periodontal disease is categorized by the destruction of periodontal tissues. Over the years, there have been several clinical techniques and material options that been investigated for periodontal defect repair/regeneration. The development of improved biomaterials for periodontal tissue engineering has significantly improved the available treatment options and their clinical results. Bone replacement graft materials, barrier membranes, various growth factors and combination of these have been used. The available bone tissue replacement materials commonly used include autografts, allografts, xenografts and alloplasts. These graft materials mostly function as osteogenic, osteoinductive and/or osteoconductive scaffolds. Polymers (natural and synthetic) are more widely used as a barrier material in guided tissue regeneration (GTR) and guided bone regeneration (GBR) applications. They work on the principle of epithelial cell exclusion to allow periodontal ligament and alveolar bone cells to repopulate the defect before the normally faster epithelial cells. However, in an attempt to overcome complications related to the epithelial down-growth and/or collapse of the non-rigid barrier membrane and to maintain space, clinicians commonly use a combination of membranes with hard tissue grafts. This article aims to review various available natural tissues and biomaterial based bone replacement graft and membrane options used in periodontal regeneration applications.