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Nishimura,Y.,Suzuki,S.,조백현,박진수,김병묵 大韓成形外科學會 1995 Archives of Plastic Surgery Vol.22 No.4
The general principle of treating a giant pigmented nevus is total resection of the lesion to prevent malignant change, followed by coverage of the skin defect with either flap or free skin graft. The problem in giant pigmented nevus lies in that enough skin to cover such a large defect is not readily available. The authors have developed a bilayer artificial skin composed of an upper silicone sheet and a lower collagen sponge sheet, and have applied it clinically with success. In using the artificial skin, the lower sheet is spontaneously converted to synthesized connective tissue matrix similar to dermis through the invasion of fibroblasts and capillaries, which allows for an easy take of a secondary skin graft. There is no significant histological and cosmetic difference between the area treated with the artificial skin plus very thin split thickness skin graft(0.2mm) and that treated with ordinary split thickness skin graft(about 0.5mm). Our recent experience with the use of an artificial skin combined with a very thin split thickness skin graft would be the best solution of the problem, at least at this stage of the research development, because it permits harvesting skin graft from the same site twice or more times, multiplying the usable skin areas in effect.
엄순찬,스즈키 시게히코,니시므라 요시히코,김용배,양순재 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.8
Application of local flaps for releasing postburn scar contracture has been limited because of a problem of invisible loss, difficulty to obtain the satisfactory result against correction of limitation of motion and possibility of contour deformity. However, proper use of local flaps, accurate designs and complete wound compression for a long term after operation enable to obtain good results in correction of some cases of postburn scar contracture. It will be related to reduce unsightly scaring when contractures are released. For this purpose, we have used a modified planimetric Z-plasty, a subcutaneous pedicle flap, a new classification V-Y plasties which was proposed based on the new concept and their combination. Proper application of local flaps corresponding to the degree of contracture and shape of burn scar have enabled to increase the use of local flaps against correction of postburn scar contracture during our past 15 years, from 1982 to 1997, we treated 235 cases of postburn scar or scar contracture in various regions except for the face. Of these, 177 cases were applicated with local flaps and we could have a good results in both aspects of function and appearance. We report our operative methods, a criterion to application of local flaps and representative results.
일산화 질소(NO)가 백서에서 도서형피판의 허혈-재관류 손상에 미치는 영향
엄순찬,김용배,스스키 스게히코,양순재,니시무라 요시히코 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.5
A free radical gas, nitric oxide NO), has many useful functions when produced under physiological conditions by neurons and endothelial cells. However, excess NO has been reported to exert cytotoxic effects by direct toxicity or by reaction with superoxide. Nitric oxide can react with superoxide to generate peroxynitrite which is as reactive as the hydroxyl radical. This study was attempted to observe formation of peroxynitrite and change in amount of NO synthase(NOS) in reperfused skin flap of rats following ischemia. 3-nitro-L-tyrosine, as direct evidence of peroxynitritemediated tissue damage, as well as endothelial and inducible NO synthase(eNOS and iNOS) were studied in ischemic and reperfused skin using western blot analysis. In addition, HNE-modified proteins, as direct evidence of oxidative tissue damage by reactive oxygen species(ROS), was also evaluated. Skin specimens were obtained over time from island skin flaps(3x3 ㎠) of rats under the following two conditions: 1) reperfusion following 5 hours of ischemia, and 2) reperfusion following 10 hours of ischemia. In reperfused skin after 5 hours of ischemia, formation of 3-nitro-L-tyrosine and HNE-modified proteins was decreased 1 hour after reperfusion. However, they were thereafter increased and reached a maximum (3-nitro-L-tyrosine: 142%,HNE-modified proteins:237%) 6 hours after reperfusion. In reperfused skin after 10 hours of ischemia, formation of 3-nitro-L-tyrosine and HNE-modified proteins was increased 3 hours post reperfusion, and reached a maximum (3-nitro-L-tyrosine:178%, HNE-modified proteins: 204%) 6 hours after reperfusion. eNOS and iNOS were decreased 1,3 and 6 hours reperfusion following both 5 and 10 hours of ischemia. These results indicate that peroxynitrite-mediated cytotoxicity is involved in ischemic reperfused skin despite the fact that the amounts of both iNOS and eNOS are decreased.
Kaoru Yamashita,Akira Tsuchitani,Hideyuki Murakami,Masanori Okuyama,Shigeru Arita,Tsunehisa Tanaka,Yaowu Mo,Yoshihiko Suzuki 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.IV
Arrayed ultrasonic microsensors using piezoelectric PZT (Pb(Zr,Ti)O3) thin lms on micromachined silicon diaphragms have been fabricated and combined with BBD (Backet Brigade Device) for signal processing. The ultrasonic sensors are designed to compose an electrical phased array for three-dimensional object detection in air. The resonant frequencies of the elements were scattered in the error range of 12 % and the objects could not be detected due to the beat in the sum of delayed element waveforms. Each element has been tuned by adequate poling less than 10 V to make its resonant frequency equal to a center value. The frequency scattering was reduced within the range of 2 % and the tuned array could give the objects by summing up of the delayed signals. Three-dimensional object detection has been demonstrated using the tuned sensor combined with the BBD delay circuit.4