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RISS 인기검색어
- 검색키워드
- 저자 : Yeh Nan-Ching (검색결과 2 건)
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Yeh Nan-Ching,Chuang Yao-Chung,Peng Hsin-Shuo,Hsu Kuo-Lin 한국기상학회 2020 Asia-Pacific Journal of Atmospheric Sciences Vol.56 No.3
The Global Satellite Mapping of Precipitation (GSMaP) was used to estimate the accumulated rainfall in May from the Mei-Yu front in Taiwan. Rainfall estimation from GSMaP during 2002–2017 were evaluated using more than 400 local gauge observations, collected from the Taiwan CentralWeather Bureau (CWB). Studies have demonstrated that the GSMaP rainfall estimation estimates can be biased, depending on the target region, elevation, and season. In this experiment, we have evaluated GSMaP over three elevation ranges. The GSMaP systemic errors for each elevation range were identified and corrected using regression analysis. The results indicated that GSMaP estimation can be improved significantly through adjustment over three elevation ranges (elevation less than 50 m, elevation of 50–100 m, and elevation higher than 100 m). For these three elevation ranges, the correlation coefficient between the GSMaP estimations and CWB rainfall data was 0.76, 0.78, and 0.59, respectively. This indicated that the GSMaP estimation was more accurate for low-elevation regions than high-elevation regions. After the proposed approaches were employed to correct the errors, the bias errors were respectively improved by 5.64(13.7%), 7.33(38.4%) and 10.52(31.2%)mmfor low-, mid- and high-elevation regions. This study demonstrated that the local correction approaches can be used to improve GSMaP estimation of Mei-Yu rainfall in Taiwan.
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( Ming-lung Yu ),( Ming-lun Yeh ),( Chi-yi Chen ),( Pin-nan Cheng ),( Ming-jong Bair ),( Jyh-jou Chen ),( Ching-chu Lo ),( Chi-ming Tai ),( Ching-yang Tsai ),( Kuo-chih Tseng ),( Chien-hung Chen ),( C 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Insufficient data regarding the treatment strategy for partial response to nucleot(s)ide analogue (NUC) raised the aim of investigating tenofovir alafenamide (TAF) switching for chronic hepatitis B (CHB) patients with advanced fibrosis and partial response to other NUCs. Methods: CHB patients with advanced fibrosis (stage 3 or 4) and under NUC (except TAF) therapy with detectable hepatitis B virus (HBV) DNA for >52 weeks are enrolled to TAF 25 mg/day for 96 weeks. The objectives are viral suppression, alanine aminotransferase (ALT) normalization and safety. Results: From Feb. 2019, 34 patients, including 21 (61.8%) with entecavir, 10 (29.4%) TDF and 3 (8.8%) lamivudine or adefovir, were enrolled (15 [44.1%] male, median 53 years). The fibroscan demonstrated a mean of 10.5 kPa (7 [20.6%] cirrhotic). Sixteen (47.1%) patients were HBV e antigen positive, seven (20.6%) had YMDD mutation. The median HBV DNA level declined from 68.5 IU/mL at enrollment to 27.0 IU/mL at 4<sup>th</sup> week, and undetectable at 12<sup>th</sup>, 24<sup>th</sup>, 36<sup>th</sup> week, respectively, after TAF switching, with undetectable HBV DNA in 14/34 (41.2%), 17/33 (51.5%), 15/25 (60.0%), and 9/15 (60.0%) patients and rate of ALT normalization (≤40 U/L) of 85.3%, 85.3%, 84.8%, 92.0%, and 80.0%, respectively, after TAF switching. (figure 1) Two patients experienced transient virological breakthrough and another one developed at the final time follow up. Serum creatinine and eGFR levels were stable after TAF switching (figure 1). Two patients early terminated including one at 12<sup>th</sup> week due to personal reason, and another one accidently died at 20<sup>th</sup> week due to acute heart attack. Others suffered only mild degrees of adverse events which were considered unrelated to treatment. Conclusions: The preliminary results demonstrated the TAF switching is effective and safe in viral suppression for CHB patients with advanced fibrosis and partial virologic responses to other NUCs.
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