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RISS 인기검색어
- 검색키워드
- 저자 : Yalin Zhou (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Jia-Le Song,Yalin Zhou,Xia Feng,Xin Zhao 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.3
The gastroprotective effect of white tea extract ethanol (WTEE) on reserpine induced gastric ulcers in KM mice was investigated. Gastric juice secretion, the pH of gastric juice, serum neuropeptides, including motilin (MOT), substance P (SP), vasoactive intestinal peptide (VIP), and somatostatin (SS) levels, and serum levels of the inflammatory cytokines TNF-α, IL-6, IL-12, and IFN-γ were measured. WTEE dose-dependently reduced reserpine-induced gastric juice secretion and increased the pH of gastric juice. WTEE increased serum levels of VIP and SS and reduced levels of MOT, SP, and inflammatory cytokines in the serum. WTEE modulated gastric expression of occludin and p38 phosphorylation in ulcer-bearing mice. WTEE has a gastroprotective effect against reserpine-induced gastric ulcers in KM mice via reduction of gastric juice secretion, modulation of serum neuropeptide levels, attenuation of serum inflammatory cytokines, and regulation of gastric levels of occludin and p38 phosphorylation.
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Gui-Jie Li,Peng Sun,Rui Wang,Yalin Zhou,Yu Qian,Xin Zhao 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.2
This project’s aim was to determine the reserpine-induced gastric ulcer preventive effect of polysaccharideof Larimichthys crocea swim bladder (PLCSB) in ICR mice. The anti-gastric ulcer effectsof polysaccharide of Larimichthys crocea swim bladder was evaluated in mice model using morphologicaltest, serum levels assay, cytokine levels assay, tissue contents analysis, reverse transcription-polymerase chain reaction (RT-PCR) analysis and western bolt assay. High concentration (50mg/kg dose) of PLCSB reduced IFN-γ as compared to low concentration (25 mg/kg dose) and controlmice. SS and VIP serum levels of PLCSB treated mice were higher than those of control mice, andMOT and SP serum levels were lower than control mice. Gastric ulcer inhibitory index of PLCSBtreatment groups mice were much lower than control mice, and the high concentration treated micewere similar to the ranitidine treated mice. The SOD and GSH-Px activities of PLCSB treated micewere higher than control mice, close to normal mice and ranitidine treated mice. PLCSB treated micealso showed the similar contents of NO and MDA to normal group. By RT-PCR and western blot assay,PLCSB significantly induced inflammation in tissues of mice by downregulating NF-κ B, iNOS, andCOX-2, and upregulating IκB-α . These results suggest that PLCSB showed a good gastric ulcerpreventive effect as the gastric ulcer drug of ranitidine. Polysaccharide of Larimichthys crocea swimbladder may be used as a drug material from marine products.
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Ying Zhang,Hengyu Lei,Pengchong Wang,Qinyuan Zhou,Jie Yu,Xue Leng,Ruirui Ma,Danyang Wang,Kai Dong,Jianfeng Xing,Yalin Dong 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Reactive oxygen species (ROS) overproduction and excessive hypoxia play pivotal roles in the initiation and progression of ulcerative colitis (UC). Synergistic ROS scavenging and generating O2 could be a promising strategy for UC treatment. Methods Ceria nanozymes (PEG-CNPs) are fabricated using a modified reverse micelle method. We investigate hypoxia attenuating and ROS scavenging of PEG-CNPs in intestinal epithelial cells and RAW 264.7 macrophages and their effects on pro-inflammatory macrophages activation. Subsequently, we investigate the biodistribution, pharmacokinetic properties and long-term toxicity of PEG-CNPs in mice. PEG-CNPs are administered intravenously to mice with 2,4,6-trinitrobenzenesulfonic acid-induced colitis to test their colonic tissue targeting and assess their anti-inflammatory activity and mucosal healing properties in UC. Results PEG-CNPs exhibit multi-enzymatic activity that can scavenge ROS and generate O2, promote intestinal epithelial cell healing and inhibit pro-inflammatory macrophage activation, and have good biocompatibility. After intravenous administration of PEG-CNPs to colitis mice, they can enrich at the site of colonic inflammation, and reduce hypoxia-induced factor-1α expression in intestinal epithelial cells by scavenging ROS to generate O2, thus further promoting disrupted intestinal mucosal barrier restoration. Meanwhile, PEG-CNPs can effectively scavenge ROS in impaired colon tissues and relieve colonic macrophage hypoxia to suppress the pro-inflammatory macrophages activation, thereby preventing UC occurrence and development. Conclusion This study has provided a paradigm to utilize metallic nanozymes, and suggests that further materials engineering investigations could yield a facile method based on the pathological characteristics of UC for clinically managing UC.
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