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Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis
Okada, Y.,Suzuki, A.,Ikari, K.,Terao, C.,Kochi, Y.,Ohmura, K.,Higasa, K.,Akiyama, M.,Ashikawa, K.,Kanai, M.,Hirata, J.,Suita, N.,Teo, Y.Y.,Xu, H.,Bae, S.C.,Takahashi, A.,Momozawa, Y.,Matsuda, K.,Momoh University of Chicago Press [etc.] 2016 American journal of human genetics Vol.99 No.2
<P>Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is challenging. Here, we conducted a large-scale MHC fine-mapping analysis of rheumatoid arthritis (RA) in a Japanese population (6,244 RA cases and 23,731 controls) population by using HLA imputation, followed by a multi-ethnic validation study including east Asian and European populations (n=7,097 and 23,149, respectively). Our study identified an independent risk of a synonymous mutation at HLA-DOA, a non-classical HLA gene, on anti-citrullinated protein autoantibody (ACPA)-positive RA risk (p=1.4 x 10(-) 9), which demonstrated a cis-expression quantitative trait loci (cis-eQTL) effect on HLA-DOA expression. Trans-ethnic comparison revealed different linkage disequilibrium (LD) patterns in HLA-DOA and HLA-DRB1, explaining the observed HLA-DOA variant risk heterogeneity among ethnicities, which was most evident in the Japanese population. Although previous HLA fine-mapping studies have identified amino acid polymorphisms of the classical HLA genes as driving genetic susceptibility to disease, our study additionally identifies the dosage contribution of a non-classical HLA gene to disease etiology. Our study contributes to the understanding of HLA immunology in human diseases and suggests the value of incorporating additional ancestry in MHC fine-mapping.</P>
Search for the H Dibaryon in (K-, K+) Reactions
Bahk,S. Y.,Chung,K. S,Chung,S. H.,Funahashi,H.,Hahn,C. H.,Hara,T.,Hirata,S.,Hoshino,K.,Ieiri,M.,Iijima,T.,Imai,K.,Ishigami,T.,Itow,Y.,Kazuno,M.,Kikuchi,K.,Kim,C. O.,Kim,D. C.,Kim,J. Y.,Kobayashi,M.,Ko 國立昌原大學校 基礎科學硏究所 1992 基礎科學硏究所論文集 Vol.3 No.-
We have studied(??) reactions from an emulsion target. The S--2H dibaryon has been searched for by the analysis of the ??? momentum spectrum together with emulsion data. No evidence of H production was observed in the mass range of 1.90-2.16 GeV/c². Upper limits for the production cross section of the H are (0.2-0.6)% of that for the quasifree ??? production at the 90% confidence level.
Tax reform in Japan: Is it welfare-enhancing?
Choi, Y.,Hirata, H.,Kim, S.H. North-Holland ; Elsevier Science Pub. Co 2017 JAPAN AND THE WORLD ECONOMY Vol.42 No.-
The ongoing tax reform in Japan, particularly a corporate income tax cut financed by an increase in consumption tax, is expected to bring positive effects on investment and output. However, the overall effects on government fiscal balance and welfare can be ambiguous, depending on the dynamic responses of macroeconomic variables to changes in tax rates. This paper aims to provide quantitative forecasts of Japanese tax reform on welfare and fiscal balance using a small open two-sector dynamic general equilibrium model calibrated to the Japanese economy. The simulation results show that under conditions of unrestricted international borrowing and no consumption habit, a corporate income tax cut of 5% financed by an increase in consumption tax improves welfare by 0.53%. However, the positive effects of corporate income tax cuts decrease when international borrowing becomes limited or consumers show habit formation. In addition, we show that a corporate income tax cut in the tradable sector generates better welfare and fiscal consequences than a tax cut in the nontradable sector.
( T. Hirata ),( Y. Maeno ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.2
일본에서 매립지에 버려지는 대량의 폐기물은 급속히 증가하며 현재 새로운 최종처분은 전무하다. 그러므로 폐기물의 적당한 매립지의 수명은 점점더 감소하고 있고 매립지에 버려지는 대량의 폐기물을 감소할수 있는 방법이 중요한 이슈중 하나이다. 대량의 폐기물 감소의 목적으로 폐기물의 효과적 이용 가능성에 대해 토의한다. 특히, 도시 고형 폐기물(MSW)의 약80%는 소각장에서 소각하고 대량의 소각재가 발생한다. 그래서, 매립지에 버려지는 소각재의 부피를 감소하는 방법또한 중요한 이슈이다. 그러므로 소각재를 새롭게 이용하는 연구를 하며, 화학적이 아니라 소각재의 역학특성을 밝히는 것이 필요하다. 몇몇의 토양역학 실험을 실행하였고, 이 논문에서는 주로 이러한 실험결과에 대해 논한다. In Japan, the amount of the waste dumped in final disposal sites is increasing rapidly and developing a new final disposal site is very hard nowadays. Therefore, the lifespan of the final disposal sites appropriate for waste is decreasing progressively. Then, one of the important issues is how to decrease the amount of waste to be dumped in the final disposal site. For the purpose of decreasing the amount of waste, the authors have been considering the possibility of effective utilization of waste. Particularly, about 80 % of municipal solid waste (MSW) is burned at the incineration plants, then a large amount of incineration residue is produced in Japan. So, how to reduce the volume of incineration residue to be dumped in the final disposal site is an important issue, too. Therefore, the authors have studied the incineration residue in order to develop its new utilization. For it, it is necessary to clarify not only the chemical but also mechanical properties of incineration residue. The authors tried to carry out some geo-mechanical tests. In this paper, the authors mainly report these test results.
STUDY ON MECHANICAL CHARACTERISTIC OF INCINERATION RESIDUE OF MSW FOR ITS EFFECTIVE UTILIZATION
( T. Hirata ),( Y. Maeno ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.1
In Japan, the amount of the waste dumped in final disposal sites is increasing rapidly and developing a new final disposal site is very hard nowadays. Therefore, the lifespan of the final disposal sites appropriate for waste is decreasing progressively. Then, one of the important issues is how to decrease the amount of waste to be dumped in the final disposal site. For the purpose of decreasing the amount of waste, the authors have been considering the possibility of effective utilization of waste. Particularly, about 80 % of municipal solid waste (MSW) is burned at the incineration plants, then a large amount of incineration residue is produced in Japan. So, how to reduce the volume of incineration residue to be dumped in the final disposal site is an important issue, too. Therefore, the authors have studied the incineration residue in order to develop its new utilization. For it, it is necessary to clarify not only the chemical but also mechanical properties of incineration residue. The authors tried to carry out some geo-mechanical tests. In this paper, the authors mainly report these test results.