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RISS 인기검색어
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- 저자 : Xiaowen Wu (검색결과 4 건)
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Wu Yuan,Wan Xiaowen,Shao Yisen,Wang Wei,Huang Wenquan,Zhu Jiajun,Jiang Lin 대한독성 유전단백체 학회 2024 Molecular & cellular toxicology Vol.20 No.2
Emerging evidence suggests that rhaponticin, a stilbene monomeric compound isolated from North China rhubarb, has been shown to exhibit significant biological activity against tumors. However, the anticancer effects and mechanisms of rhaponticin in tongue squamous cell carcinoma (TSCC) remain elusive.We investigated the changes of migration and invasion abilities and EMT progression of TSCC cells treated with different concentrations of rhaponticin under hypoxia, as well as the possible mechanisms, in order to initially explore the effects of rhaponticin on the biological characteristics of TSCC cells under hypoxia.The number of cell migration and invasion was prominently increased, E-cadherin protein was down-regulated, and N-cadherin and HIF-1α protein expression was elevated under hypoxia. Rhaponticin intervention strikingly prevented the increased abilities of migration and invasion and EMT of TSCC cells under hypoxia. This was followed by further validation finding that rhaponticin indeed leads to reduced HIF-1α post-transcriptional activity. Mechanistically, rhaponticin may bind to aryl-hydrocarbon nuclear translocator (ARNT) domain of HIF-1α.Rhaponticin repressed the invasion and migration abilities and EMT process of TSCC cells under a hypoxic environment in vitro by targeted suppression of HIF-1α. Background Emerging evidence suggests that rhaponticin, a stilbene monomeric compound isolated from North China rhubarb, has been shown to exhibit significant biological activity against tumors. However, the anticancer effects and mechanisms of rhaponticin in tongue squamous cell carcinoma (TSCC) remain elusive. Objective We investigated the changes of migration and invasion abilities and EMT progression of TSCC cells treated with different concentrations of rhaponticin under hypoxia, as well as the possible mechanisms, in order to initially explore the effects of rhaponticin on the biological characteristics of TSCC cells under hypoxia. Results The number of cell migration and invasion was prominently increased, E-cadherin protein was down-regulated, and N-cadherin and HIF-1α protein expression was elevated under hypoxia. Rhaponticin intervention strikingly prevented the increased abilities of migration and invasion and EMT of TSCC cells under hypoxia. This was followed by further validation finding that rhaponticin indeed leads to reduced HIF-1α post-transcriptional activity. Mechanistically, rhaponticin may bind to aryl-hydrocarbon nuclear translocator (ARNT) domain of HIF-1α. Conclusions Rhaponticin repressed the invasion and migration abilities and EMT process of TSCC cells under a hypoxic environment in vitro by targeted suppression of HIF-1α.
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( Wei Deng ),( Xiaowen Wu ) 이화여자대학교 통역번역연구소 2019 T&I review Vol.9 No.-
The Chinese neologism in the field of social and cultural life reflects the continual evolution of contemporary Chinese society. In order to communicate to the French-speaking countries and regions in the world the most recent Chinese concepts expressed in the form of neologisms in their native language, a distinctive French translation is indispensable. Translation methods adopted to do this and the acceptability of the proposed translation, evaluated by the French-speaking native speakers, are at the center of this work. Based on 100 Chinese social and cultural neologisms and their translations into French, extracted from the international translation project, "The key words about China", we have studied four methods of translation: literal translation, free translation, translation to French help of the third language and transliteration. Using a questionnaire, we evaluated with 21 native French speakers the acceptability of the proposed translations from a global, syntactical and lexical point of view. Analysis of the data collected shows that literally translated neologisms are the most accepted. On the contrary, those translated using Chinese phonetic transcription (transliteration) are considered the least acceptable. In addition, the survey also reveals that the ease of understanding of the translation has a great influence on the acceptability of the translation, under different aspects, this influence manifesting itself especially in the transliteration and in the translation with the help of the third language. Finally, at the end of this study, we provide some tips for improving the acceptability of translation.
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Experimental study on wave motion of partial air cushion supported catamaran
Jinglei Yang,Hanbing Sun,Xiaowen Li,Defeng Wu 대한조선학회 2023 International Journal of Naval Architecture and Oc Vol.15 No.-
To study the performance of partial air cushion-supported catamaran (PACSCAT), which is sailing with a flexible air seal in waves, this paper uses the model tests, and research the motion characteristics of PACSCAT at different wavelengths, by monitoring the boundaries of heave, pitch, acceleration, air cushion pressure. Firstly this paper introduces the test situation of PACSCAT in the towing tank and introduces the test method, equipment, and test conditions. Second, this paper extracts the test data, analyzes the features of heave, pitch, acceleration, and air cushion pressure, and studies their linear and nonlinear changes in regular waves. Thirdly this paper analyzes the nonlinear air leakage flow of the bow of PACSCAT in detail under the test conditions and studies the internal and external free liquid surface under different conditions.
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