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RISS 인기검색어
- 검색키워드
- 저자 : Widyarini, Sitarina (검색결과 3 건)
- 무료
- 기관 내 무료
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The phyto-oestrogens: its anticarcinogenic and antioxidant activity-a review
Widyarini, Sitarina,Reeve, Vivienne E. Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.2
The isoflavonoids comprise a group of phyto-oestrogens that have useful biological activities including oestrogenic, antioxidant and anticancer. As dietary components for humans, they are bioavailable from leguminous vegetables (such as genistein from soybean), and have been well-documented to have numerous health benefits. A wide range of epidemiological studies in humans and limited studies in animals have identified isoflavonoids as potential chemopreventive agents against hormone-dependent cancers. Therefore, an attempt has been made through this review to summarise the information in the mechanisms aspect of isoflavonoid phyto-oestrogens in inhibiting cancer in vitro and in vivo in the models of human cancers.
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Sitarina Widyarini 대한수의학회 2006 Journal of Veterinary Science Vol.7 No.3
Equol, an isoflavonoid metabolite produced from the dietary isoflavone daidzein by the gut microflora in mammals, has been found to protect not only against ultraviolet (UV) radiation-induced cutaneous inflammation and photoimmune suppression, but also have antiphotocarcinogenic properties in mice. Because the state of DNA damage has been correlated with suppression of the immune system and photocarcinogenesis, we have therefore examined the potential of equol to offer protection from solar-simulated UV (SSUV) radiation-induced DNA damage in hairless mice by the immunohistochemical approach using monoclonal antibody specific for cyclobutane pyrimidine dimers (CPDs; H3 antibody). Topical application of 20 µM equol lotion, which was applied both before and after SSUV significantly reduced the number of CPDs. This reduction was evident immediately after SSUV exposure, at 1 h after exposure, and at 24 h after exposure, revealing 54%, 50%, and 26% reduction in CPDs, respectively. When the same concentration was applied for 5 consecutive days after SSUV exposure, there was no significant difference in the reduction of CPDs immediately after SSUV irradiation or at 1 hour afterwards, but there were significant reductions of 23% and 42% at 24 and 48 h after SSUV exposure, respectively. Despite apparently reducing the number of CPDs post-SSUV, topically applied equol did not appear to increase the rate of dimer removal. To conclude, equol applied topically prior to SSUV irradiation offers protection against CPD formation in hairless mice, possibly by acting as a suncreen and thus inhibiting DNA photodamage.
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Yustina Sri Hartini,Sitarina Widyarini,Laurentius Hartanto Nugroho 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.4
A single active compound isolated from a plant extract may show a lower, equal, or greater activity compared to its extract. The two neolignans (Pc-1 and Pc-2) has been isolated from red betel (Piper crocatum Ruiz & Pav.) leaf. The aim of this study was to compare the phagocytic activity of macrophage and histopathological feature in mice treated with Pc-1, Pc-2 and its Pc-extract. Listeria monocytogenes was used to induce Balb/c mice immune response. Peroral administration of Pc-1 and Pc-2 and red betel leaf methanolic Pc-extract were carried out. The phagocytic effect was determined by macrophage phagocytosis and nitric oxide (NO) assays. The morphological feature of liver and kidney were observed using light microscope. The level of apartate transaminase (AST serum) and alanine transaminase (ALT serum) were also measured from the blood serum before and after L. monocytogenes infection. The results shows that the macrophage phagocytic activity of given 450 mg/kg body weight Pc-extract was equal to 5 mg/kg body weight of Pc-1 and Pc-2. The activity pattern of percentage phagocytosis, index phagocytosis, and efficiency phagocytosis of Pc-extract, Pc-1, and Pc-2 were similar, as well as the NO production. A certain dose of Pc-extract and both isolated compound reduced the level of AST while there were no effect on ALT level. There were no histopathological features differences in the liver after treated with Pc-extract and Pc-1. However, Pc-2 treatment caused hydropic degeneration on liver. Therefore it can be concluded that there were equal activity between Pc-extract and the isolated compound in certain dose. The Pc-extract and isolated compound reduced the level of AST while there were no effect on ALT. The only Pc-2 affected the histopathological features of the liver.
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