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- 저자 : Wendel Batista da Silveira (검색결과 2 건)
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Eduardo Luís Menezes de Almeida,Eduard J. Kerkhoven,Wendel Batista da Silveira 한국생물공학회 2024 Biotechnology and Bioprocess Engineering Vol.29 No.1
Non-conventional yeasts are promising cell factories to produce lipids and oleochemicals, metabolites of industrial interest ( e.g ., organics acids, esters, and alcohols), and enzymes. They can also use diff erent agro-industrial by-products as substrates within the context of a circular economy. Some of these yeasts can also comprise economic and health burdens as pathogens. Genome-scale metabolic models (GEMs), networks reconstructed based on the genomic and metabolic information of one or more organisms, are great tools to understand metabolic functions and landscapes, as well as propose engineering targets to improve metabolite production or propose novel drug targets. Previous reviews on yeast GEMs have mainly focused on the history and the evaluation of Saccharomyces cerevisiae modeling paradigms or the accessibility and usability of yeast GEMs. However, they did not describe the reconstruction strategies, limitations, validations, challenges, and research gaps of non-conventional yeast GEMs. Herein, we focused on the reconstruction of available non- Saccharomyces GEMs, their validation, underscoring the physiological insights, as well as the identifi cation of both metabolic engineering and drug targets. We also discuss the challenges and knowledge gaps and propose strategies to boost their use and novel reconstructions.
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Screening of Yeasts Isolated from Brazilian Environments for the 2-Phenylethanol (2-PE) Production
Lorena Azevedo de Lima,Raphael Hermano Santos Diniz,Marisa Vieira de Queiroz,Luciano Gomes Fietto,Wendel Batista da Silveira 한국생물공학회 2018 Biotechnology and Bioprocess Engineering Vol.23 No.3
Phenylethanol alcohol, or 2-phenylethanol (2-PE) production by yeasts has been considered a promising alternative to its chemical synthesis. In order to evaluate the potential of yeast strains isolated from different Brazilian environments, we evaluated the 2-PE production of 267 strains. Among them, the Kluyveromyces marxianus CCT 7735 yeast stood out as being the best 2-PE producer. The K. marxianus CCT 7735 growth was impaired by 2-PE; nevertheless, this effect is less pronounced than the inhibition reported for certain Saccharomyces cerevisiae strains. The maximum 2-PE titer obtained under optimized conditions was 3.44 g/L, 28% higher than the titer achieved under unoptimized conditions. The optimized conditions were: 30ºC, and glucose and L-phe concentrations of 3.0 and 4.0 g/L, respectively. Moreover, the specific production rate of 2-PE increased twofold compared to the unoptimized conditions.
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