http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Weidong Jia (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Jian Gao,Fusheng Deng,Weidong Jia 한국유방암학회 2019 Journal of breast cancer Vol.22 No.2
Purpose: Breast cancer has become a major public health threat in the current society. Anthracycline doxorubicin (DOX) is a widely used drug in breast cancer chemotherapy. We aimed to investigate the immunogenic death of breast tumor cells caused by DOX, and detect the effects of combination of DOX and a small molecule inhibitor in tumor engrafted mouse model. Methods: We used 4T1 breast cancer cells to examine the anthracycline DOX-mediated immunogenic death of breast tumor cells by assessing the calreticulin exposure and adenosine triphosphate and high mobility group box 1 release. Using 4T1 tumor cell-engrafted mouse model, we also detected the expression of indoleamine 2,3-dioxygenase (IDO) in tumor tissues after DOX treatment and further explored whether the specific small molecule IDO1 inhibitor NLG919 combined with DOX, can exhibit better therapeutic effects on breast cancer. Results: DOX induced immunogenic cell death of murine breast cancer cells 4T1 as well as the upregulation of IDO1. We also found that treatment with NLG919 enhanced kynurenine inhibition in a dose-dependent manner. IDO1 inhibition reversed CD8+ T cell suppression mediated by IDO-expressing 4T1 murine breast cancer cells. Compared to the single agent or control, combination of DOX and NLG919 significantly inhibited the tumor growth, indicating that the 2 drugs exhibit synergistic effect. The combination therapy also increased the expression of transforming growth factor-β, while lowering the expressions of interleukin-12p70 and interferon-γ. Conclusion: Compared to single agent therapy, combination of NLG919 with DOX demonstrated better therapeutic effects in 4T1 murine breast tumor model. IDO inhibition by NLG919 enhanced the therapeutic efficacy of DOX in breast cancer, achieving synergistic effect.
-
Preparation of biomass-based yam solar absorber for enhanced solar evaporation application
Ting Li,Juan Jia,Yanqing Wang,Hanxue Sun,Jiyan Li,Zhaoqi Zhu,Weidong Liang 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.11
The solar evaporation system has become a research hotspot in the field of photothermal conversion technology in recent years because of its high photothermal conversion efficiency and practicality of promotion. Biomass solar absorbers have excellent solar absorption properties and high solar-water vapor conversion, but they have the limitations of long feedstock production cycle and high carbonization temperature. As a kind of biomass materials, yam is not only inexpensive, but also has a short production cycle and rich pore structures. Therefore, in this paper, a yam based solar absorber with rich pore structure was prepared, and the photothermal conversion efficiency of the absorber was further investigated. The yam was treated with freeze-dried method and carbonized at different temperatures to obtain yam solar absorbers. Then the thermal stability and porosity of solar absorber was found to gradually rise as the treatment temperature increased. The solar absorption rate of the carbonized yam was close to 90% in the near UV-visible region. Solar-water vapor control experiments with different treatments of the solar absorber of the yam were carried out in simulated solar-driven interface steam generation system (SISGS). An absorber treated at 200 °C in the sun was found to have the best performance with a solar-water vapor conversion of about 90% and a water evaporation rate of 1.3164 kg m−2 h−1.
-
Substrate effect on phonon in graphene layers
Xiao Guo,Yongsong Wang,Siwen You,Dingbang Yang,Guiping Jia,Fei Song,Weidong Dou,Han Huang 한국탄소학회 2023 Carbon Letters Vol.33 No.5
Graphene exhibits high carrier mobility and concentration as well as other remarkable properties. Among them, the thermal behaviors of phonon modes play important roles in the application of optical and electronic devices. Here, A–A stacked graphene were proved well by Raman investigation on G and 2D modes. Temperature-dependent Raman scattering measurements on graphene with various number of layers on different substrates were conducted in the temperature range of 80–460 K. The first-order temperature coefficient of single layer graphene (SLG) on SiO2/ Si substrate is obviously smaller than that on Cu foil, indicating that the substrate effect attributes a great impact on graphene phonon temperature dependence. The first-order temperature coefficients of multilayer graphene linearly decrease as the number of layers increases, attributed to the reduction of substrate effect in phonon behaviors, rather than to the anharmonic phonon–phonon (ph–ph) coupling or thermal expansion.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
