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Modified Renshen Wumei Decoction Alleviates Intestinal Barrier Destruction in Rats with Diarrhea
( Zhiwei Guan ),( Qiong Zhao ),( Qinwan Huang ),( Zhonghe Zhao ),( Hongyun Zhou ),( Yuanyuan He ),( Shanshan Li ),( Shifang Wan ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.9
Modified Renshen Wumei decoction (MRWD), a famous traditional Chinese medicine, is widely used for treating persistent diarrhea. However, as the mechanism by which MRWD regulates diarrhea remains unknown, we examined the protective effects of MRWD on intestinal barrier integrity in a diarrhea model. In total, 48 male rats were randomly distributed to four treatment groups: the blank group (CK group), model group (MC group), Medilac-Vita group (MV group) and Chinese herb group (MRWD group). After a 21-day experiment, serum and colon samples were assessed. The diarrhea index, pathological examination findings and change in D-lactate and diamine oxidase (DAO) contents illustrated that the induction of diarrhea caused intestinal injury, which was ameliorated by MV and MRWD infusion. Metabolomics analysis identified several metabolites in the serum. Some critical metabolites, such as phosphoric acid, taurine, cortisone, leukotriene B4 and calcitriol, were found to be significantly elevated by MRWD infusion. Importantly, these differences correlated with mineral absorption and metabolism and peroxisome proliferator-activated receptor (PPAR) pathways. Moreover, it significantly increased the expression levels of TLR4, MyD88 and p-NF-κB p65 proteins and the contents of IL-1 and TNF-α, while the expression levels of occludin, claudin-1 and ZO-1 proteins decreased. These deleterious effects were significantly alleviated by MV and MRWD infusion. Our findings indicate that MRWD infusion helps alleviate diarrhea, possibly by maintaining electrolyte homeostasis, improving the intestinal barrier integrity, and inhibiting the TLR4/NF-κB axis.
Tongyu Li,Weiwei Shi,Jie Yao,Jingyun Hu,Qiong Sun,Jing Meng,Jian Wan,Haihan Song,Hangxiang Wang 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1
Background: Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has not been reported and remains challenging. Methods: Synthesized chrysotile nanotubes (SCNTs) with a relatively uniform length (~ 200 nm) have been designed to deliver an siRNA against the oncogenic circPRMT5 (si-circPRMT5) inhibit circPRMT5. In addition, the antitumor effects and safety evaluation of SCNTs/si-circPRMT5 was assessed with a series of in vitro and in vivo assays. Results: The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5’s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of circPRMT5. In vitro, SCNTs encapsulating si-circPRMT5 could inhibit bladder cancer cell growth and progression. In vivo, SCNTs/si-circPRMT5 inhibited growth and metastasis in three bladder tumor models (a subcutaneous model, a tail vein injection lung metastatic model, and an in situ model) without obvious toxicities. Mechanistic study showed that SCNTs/sicircPRMT5 regulated the miR-30c/SNAIL1/E-cadherin axis, inhibiting bladder cancer growth and progression. Conclusion: The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer. Keywords: Synthesized chrysotile nanomaterials, Gene therapy, Targeted delivery, CircPRMT5, SiRNA, Bladder cancer
An Xin,Xing Guannan,Wang Jing,Tian Yanhong,Liu Yunfang,Wan Qiong 한국탄소학회 2021 Carbon Letters Vol.31 No.4
The carbon spheres (CSs) synthesized by an ultrasonic-spray pyrolysis method were activated for supercapacitor electrode. There are plenty of cracks on the surface of the activated carbon spheres (ACSs), which expend with increasing the activation temperature and activator dosage. The specifc capacitance of ACSs increases with the activation temperature and activator dosage and reach to maximal value at certain conditions. Importantly, the ACS sample activated at relatively low activation temperature (600 °C) and 7 of mass ratio of KOH to CSs has the highest specifc capacitance (about 209 F g−1 at 50 mA g−1 of current density) and indicates the excellent cycling stability after 1000 consecutive charge–discharge cycles. Furthermore, the graphene sheets could be found in the samples that were activated at 1000 °C. And the electrode prepared by the sample has the very low series resistance because of the excellent conductivity of the formed graphene sheets.
Lijie Tang,Yan Ma,Caixia Yang,Enxiang Liang,Hong Yin,Qiong Wan,Jiance Zhang,Wei Wang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.118 No.-
Flexible energy storage devices are susceptible to damage, which might result in safety issues. In thispaper, a self-healing flexible P(AAPBA-co-P4-AC) gel electrolyte based on dynamic borate bond crosslinkingstrategy is reported. On the one hand, it is simple to process into complicated shapes or patterns,and on the other hand, it could rapidly return to its original state after stress damage. Even after ten timesself-healing, the gel has the same mechanical properties as the non-damaged gel. Furthermore, this gelcan also be applied in all-solid-state supercapacitors without the need of extra electrolytes. Becausethe gel has a large number of hydroxyl groups, it has a high affinity for the activated carbon electrode,and the supercapacitors can maintain 100% initial performance under various angles or strains. Afterten thousand times cycles charge–discharge, the supercapacitors using the gel after twenty times selfhealingprocess can retain 90% of its initial capacity, which is only 4% lower than the non-damagingsupercapacitors, demonstrating high self-healing ability.