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Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes
Sarfraz Ahmad,Werner Seebacher,Volker Wolkinger,Armin Presser,Johanna Faist,Marcel Kaiser,Reto Brun,Robert Saf,Robert Weis 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.8
Some antimalarial agents in use typically bear basic side chains as ligands. Such ligands were attached to the amino substituent of a bridgehead atom of already antiprotozoal active 3-azabicyclo[3.2.2]nonanes. Structure verification was done by NMR measurements. The new compounds were tested for their antiplasmodial and antitrypanosomal activities against Plasmodium falciparum K1 (multiresistant) and Trypanosoma brucei rhodesiense as well as for their cytotoxicity against L6 cells. Theiractivities are compared to those of already prepared compounds and structure–activity relationships are discussed.