RISS 검색 - 국내학술지논문

무료
기관 내 무료
유료

내보내기
내책장담기
한글로보기

정확도순

내림차순

내림차순

10개씩 출력

1
Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis

Choi, J.H.,Cheong, C.,Dandamudi, Durga B.,Park, C.,Rodriguez, A.,Mehandru, S.,Velinzon, K.,Jung, I.H.,Yoo, J.Y.,Oh, G.,Steinman, Ralph M. Cell Press 2011 Immunity Vol.35 No.5
- 원문보기
Early events in atherosclerosis occur in the aortic intima and involve monocytes that become macrophages. We looked for these cells in the steady state adult mouse aorta, and surprisingly, we found a dominance of dendritic cells (DCs) in the intima. In contrast to aortic adventitial macrophages, CD11c+MHC IIhi DCs were poorly phagocytic but were immune stimulatory. DCs were of two types primarily: classical Flt3-Flt3L signaling-dependent, CD103+CD11b- DCs and macrophage-colony stimulating factor (M-CSF)-dependent, CD14+CD11b+DC-SIGN+ monocyte-derived DCs. Both types expanded during atherosclerosis. By crossing Flt3-/- to Ldlr-/- atherosclerosis-prone mice, we developed a selective and marked deficiency of classical CD103+ aortic DCs, and they were associated with exacerbated atherosclerosis without alterations in blood lipids. Concomitantly, the Flt3-/-Ldlr-/- mice had fewer Foxp3+ Treg cells and increased inflammatory cytokine mRNAs in the aorta. Therefore, functional DCs are dominant in normal aortic intima and, in contrast to macrophages, CD103+ classical DCs are associated with atherosclerosis protection.
2
Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract

Ruane, Darren,Brane, Lucas,Reis, Bernardo Sgarbi,Cheong, Cheolho,Poles, Jordan,Do, Yoonkyung,Zhu, Hongfa,Velinzon, Klara,Choi, Jae-Hoon,Studt, Natalie,Mayer, Lloyd,Lavelle, Ed C.,Steinman, Ralph M.,Mu The Rockefeller University Press 2013 The Journal of experimental medicine Vol.210 No.9
- 원문보기
Developing efficacious vaccines against enteric diseases is a global challenge that requires a better understanding of cellular recruitment dynamics at the mucosal surfaces. The current paradigm of T cell homing to the gastrointestinal (GI) tract involves the induction of α4β7 and CCR9 by Peyer’s patch and mesenteric lymph node (MLN) dendritic cells (DCs) in a retinoic acid–dependent manner. This paradigm, however, cannot be reconciled with reports of GI T cell responses after intranasal (i.n.) delivery of antigens that do not directly target the GI lymphoid tissue. To explore alternative pathways of cellular migration, we have investigated the ability of DCs from mucosal and nonmucosal tissues to recruit lymphocytes to the GI tract. Unexpectedly, we found that lung DCs, like CD103+ MLN DCs, up-regulate the gut-homing integrin α4β7 in vitro and in vivo, and induce T cell migration to the GI tract in vivo. Consistent with a role for this pathway in generating mucosal immune responses, lung DC targeting by i.n. immunization induced protective immunity against enteric challenge with a highly pathogenic strain of Salmonella. The present report demonstrates novel functional evidence of mucosal cross talk mediated by DCs, which has the potential to inform the design of novel vaccines against mucosal pathogens.

내보내기
내책장담기
한글로보기

정확도순

내림차순

내림차순

10개씩 출력

맨처음 페이지로 1 맨끝 페이지로

상세검색

RISS 보유자료

상세검색

해외전자자료

연관 검색어 추천