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Ongoing endeavors to detect mobilization of transposable elements
Yujeong Lee,Una Ha,Sungjin Moon 생화학분자생물학회 2022 BMB Reports Vol.55 No.7
Transposable elements (TEs) are DNA sequences capable ofmobilization from one location to another in the genome. Sincethe discovery of ‘Dissociation (Dc) locus’ by Barbara McClintockin maize (1), mounting evidence in the era of genomics indicatesthat a significant fraction of most eukaryotic genomes is composedof TE sequences, involving in various aspects of biologicalprocesses such as development, physiology, diseasesand evolution. Although technical advances in genomics havediscovered numerous functional impacts of TE across species,our understanding of TEs is still ongoing process due to challengesresulted from complexity and abundance of TEs in thegenome. In this mini-review, we briefly summarize biology ofTEs and their impacts on the host genome, emphasizing importanceof understanding TE landscape in the genome. Then,we introduce recent endeavors especially in vivo retrotranspositionassays and long read sequencing technology for identifyingde novo insertions/TE polymorphism, which will broaden ourknowledge of extraordinary relationship between genomic cohabitantsand their host.