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- 저자 : Toraih, Eman A (검색결과 2 건)
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Toraih, Eman A,Fawzy, Manal S,Elgazzaz, Mona G,Hussein, Mohammad H,Shehata, Rasha H,Daoud, Hisham G Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
MicroRNAs, a novel class of small non-coding RNAs, are key players in many cellular processes, including cell proliferation, differentiation, invasion and regeneration. Tissue and circulatory microRNAs could serve as useful clinical biomarkers and deregulated expression levels have been observed in various cancers. Gene variants may alter microRNA processing and maturation. Thus, we aimed to investigate the association of MIR-196a2 rs11614913 (C/T), MIR-499a rs3746444 (A/G) polymorphisms and their combination with cancer susceptibility in an Egyptian population. Sixty five renal cell carcinoma (RCC) and 60 hepatocellular carcinoma (HCC) patients and 150 controls were enrolled in the study. They were genotyped using real-time polymerase chain reaction technology. Both $miR-196a2^*T$ and $miR-499a*G$ were associated with RCC risk, but only $miR-196a^*T$ was associated with HCC development. Carriage of the homozygote combinations ($MIR196a2^*TT+MIR499a^*AA$) and ($MIR196a2^*CC+MIR499a^*GG$) was associated with 25 and 48 fold elevation of likelhood to develop RCC, respectively. The miR-196a2 SNP was also linked with larger tumor size in RCC and advanced tumor stage in HCC. miR-196a2 and miR-499a combined genotypes were associated with RCC and HCC. Further functional analysis of SNPs is required to confirm relationships between genotypes and phenotypes.
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Nagla A. El‑Sherbeeny,Afaf T. Ibrahiem,Howaida S. Ali,Noha E. Farag,Eman A. Toraih,Sawsan A. Zaitone 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.7
This work tested the role of carbamazepine inalleviating alloxan-induced diabetic neuropathy and theenhancement of spinal plasticity. Mice were randomizedinto four groups: normal, control, carbamazepine (25-mg/kg) and carbamazepine (50-mg/kg). Nine weeks after inductionof diabetes, symptoms of neuropathy were confirmedand carbamazepine (or vehicle) was given every other dayfor five weeks. After completing the treatment period, micewere sacrificed and the pathologic features in the spinal cordand the sciatic nerves were determined. The spinal cordswere evaluated for synaptic plasticity (growth associated protein-43, GAP43), microglia cell expression (by CD11b)and astrocyte expression (glial fibrillary acidic protein,GFAP). Further, sciatic nerve expression of Nav1.5 wasmeasured. Results revealed that carbamazepine 50 mg/kgprolonged the withdrawal threshold of von-Frey filamentsand increased the hot plate jumping time. Carbamazepineimproved the histopathologic pictures of the sciatic nervesand spinal cords. Spinal cord of carbamazepine-treatedgroups had enhanced expression of GAP43 but lower contentof CD11b and GFAP. Furthermore, specimens from thesciatic nerve indicated low expression of Nav1.5. In conclusion,this work provided evidence, for the first time, that thepreventive effect of carbamazepine against diabetic neuropathyinvolves correction of spinal neuronal plasticity and gliacell expression.
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