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A dynamic performance management approach to support local strategic planning
Carmine Bianchi,Salvatore Tomaselli 한국행정학회 2015 International Review of Public Administration Vol.20 No.4
In spite of efforts devoted in the last decades to local strategic planning, such field of research and practice has been frequently characterized by a lack of implementation. We argue here that this phenomenon is due to the limitations of the static and linear approach to local strategic planning in fostering the development of common shared view among policy makers on the relevant system’s structure and behavior. By means of a case-study, we illustrate how an approach based on system dynamics modeling applied to Performance Management can be useful to overcome such weaknesses. The proposed approach enhances a better understanding of the causes and effects related to adopted policies, undertaken actions and targeted results. This helps key-players in an area to overcome possible barriers to collaboration, and therefore to adopt a combined “institutional and inter-institutional” perspective of performance.
Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling
Jeong, Myong-Ho,Kim, Hyun-Ji,Pyun, Jung-Hoon,Choi, Kyu-Sil,Lee, Dong I.,Solhjoo, Soroosh,O'Rourke, Brian,Tomaselli, Gordon F.,Jeong, Dong Seop,Cho, Hana,Kang, Jong-Sun National Academy of Sciences 2017 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.114 No.8
<P>On pathological stress, Wnt signaling is reactivated and induces genes associated with cardiac remodeling and fibrosis. We have previously shown that a cell surface receptor Cdon (cell-adhesion associated, oncogene regulated) suppresses Wnt signaling to promote neuronal differentiation however its role in heart is unknown. Here, we demonstrate a critical role of Cdon in cardiac function and remodeling. Cdon is expressed and predominantly localized at intercalated disk in both mouse and human hearts. Cdon-deficient mice develop cardiac dysfunction including reduced ejection fraction and ECG abnormalities. Cdon(-/-) hearts exhibit increased fibrosis and up-regulation of genes associated with cardiac remodeling and fibrosis. Electrical remodeling was demonstrated by up-regulation and mislocalization of the gap junction protein, Connexin 43 (Cx43) in Cdon(-/-) hearts. In agreement with altered Cx43 expression, functional analysis both using Cdon(-/-) cardiomyocytes and shRNA-mediated knockdown in rat cardiomyocytes shows aberrant gap junction activities. Analysis of the underlying mechanism reveals that Cdon(-/-) hearts exhibit hyperactive Wnt signaling as evident by beta-catenin accumulation and Axin2 up-regulation. On the other hand, the treatment of rat cardiomyocytes with a Wnt activator TWS119 reduces Cdon levels and aberrant Cx43 activities, similarly to Cdon-deficient cardiomyocytes, suggesting a negative feedback between Cdon and Wnt signaling. Finally, inhibition of Wnt/beta-catenin signaling by XAV939, IWP2 or dickkopf (DKK)1 prevented Cdon depletion-induced up-regulation of collagen 1a and Cx43. Taken together, these results demonstrate that Cdon deficiency causes hyperactive Wnt signaling leading to aberrant intercellular coupling and cardiac fibrosis. Cdon exhibits great potential as a target for the treatment of cardiac fibrosis and cardiomyopathy.</P>