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RISS 인기검색어
- 검색키워드
- 저자 : Thangaraj Parimelazhagan (검색결과 6 건)
- 무료
- 기관 내 무료
- 유료
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Antitumor and Wound Healing Properties of Rubus ellipticus Smith.
Thangaraj Parimelazhagan,Blassan Plackal George,Yamini T. Kumar,Thankarajan Sajeesh 사단법인약침학회 2015 Journal of Acupuncture & Meridian Studies Vol.8 No.3
The present investigation has been undertaken to study the antioxidant, antitumor, and wound healing properties of Rubus ellipticus. The R. ellipticus leaves were extracted using organic solvents in Soxhlet and were subjected to in vitro antioxidant assays. R. ellipticus leaf methanol (RELM) extract, which showed higher in vitro antioxidant activity, was taken for the evaluation of in vivo antioxidant, antitumor, and wound healing properties. Acute oral and dermal toxicity studies showed the safety of RELM up to a dose of 2 g/kg. A significant wound healing property was observed in incision, excision, and Staphylococcus aureus-induced infected wound models in the treatment groups compared to the control group. A complete epithelialization period was noticed during the 13th day and the 19th day. A 250-mg/kg treatment was found to prolong the life span of mice with Ehrlich ascite carcinoma (EAC; 46.76%) and to reduce the volume of Dalton's lymphoma ascite (DLA) solid tumors (2.56 cm3). The present study suggests that R. ellipticus is a valuable natural antioxidant and that it is immensely effective for treating skin diseases, wounds, and tumors.
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Karuppusamy Arunachalam,Shanmugam Saravanan,Thangaraj Parimelazhagan 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.1
The present study was carried out with ungerminated seed embryos of palmryah to evaluate nutritional quality with respect to minerals and fiber components, total phenols, and antioxidant properties. It is found to be good source of carbohydrate, fiber, fat, amino acids, and protein. Analysis of macro and micronutrient composition showed potent source of sodium, potassium, calcium, magnesium,zinc, and iron. In vitro antioxidant activity was evaluated by different assays, including 2,2-diphenylpicryl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2'azinobis (3-ethylbenzothiozoline-6-sulfonic acid) disodium salt (ABTS^•+)assay, ferric reducing antioxidant power (FRAP) assay,phospomolybdenum reduction assay, metal chelating activity,and hydroxyl radical scavenging activity. The results indicate that this plant seed embryo possesses micro, macro nutrients and antioxidant properties and has nutraceuticals potential for the treatment of malnutrition.
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Rajan Murugan,Karuppusamy Arunachalam,Thangaraj Parimelazhagan 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.1
In the present investigation, phenolics (36.6 g gallic acid equivalents (GAE)/100 g extract), tannin (21.6 g GAE/100 g extract), and flavonoid content (67.5 g rutin equivalents/100 g extract) were found to be highest in acetone extract. Ficus (Ficus amplissima) acetone extract showed maximum antioxidant activity in phosphomolybdenum (958.8 mg ascorbic acid equivalents/g extract), DPPH (1.6μg/mL), ferric reducing antioxidant power (2,993 mmol Fe (II)/g extract), and metal chelating (39.7 mg EDTA equivalents/g extract) assays. In anti-inflammatory study,400 mg/kg acetone extract showed maximum reduction in the paw volume compare to indomethacin. GC-MS analysis indicated that bark contain rich source of non-polar compounds like Lup-20(29)-en-3-yl acetate (33.04%). Hence, Ficus can be valuable source for antioxidant and anti-inflammatory and seemed to be applicable in medicine.
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Evaluation of Antioxidant and Pharmacological Properties of Psychotria nilgiriensis Deb & Gang
Murugaiyan Iniyavan,Devadoss Sangeetha,Shanmugam Saravanan,Thangaraj Parimelazhagan 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.5
The purpose of the present study was to investigate the antioxidant and pharmacological properties of fruit, stem, and leaf extract of Psychotria nilgiriensis. Acetone extract of P. nilgiriensis fruit was found to have highest total phenolics (505.74 mg GAE/g extract), tannin (460.78 mg GAE/g extract), and flavonoid (67.78 mg RE/g extract) content. In vitro antioxidant studies revealed that the acetone extract of fruit posses significant antioxidant activity in DPPH radical scavenging, ABTS•+, and ferric reducing antioxidant power (FRAP) assays. In vivo studies revealed that P. nilgiriensis fruit (400 mg/kg) showed good analgesic activity in hot plate method (72%), acetic acid induced writhing test (53%) and also showed significant in carrageenan induced inflammation (73.54%). GC/MS analysis of fruit showed the presence of sesquiterpenes. The study highlights the significant medicinal value of the plant.
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Evaluation of Nutraceutical Properties of Laportea interrupta (L.) Chew
Charyacheri Swathi Krishna,Thankarajan Sajeesh,Thangaraj Parimelazhagan 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.2
In the present study Laportea interrupta wasanalysed for nutritional, antioxidant, and antipyretic properties. Leaves contained significant amount of carbohydrates(19.80 g/100 g), proteins (31.30 g/100 g), starch (15.40 g/100 g), essential amino acids, and minerals. Ethanolextracts of flowers and roots revealed high total phenolic(46.35mg gallic acid equivalents/g of extract) and flavonoidcontents (96.67mg rutin equivalents/g of extract) respectively. Antioxidant assays showed that ethanol root extractpossessed a strong 2,2-diphenyl-1-picrylhydrazyl radicalscavenging capacity (IC50: 32.34 μg/mL), a 2,2'-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) radical cationscavenging activity (1,072.57 μM trolox equivalents/g ofextract), and a ferric reducing ability (9,456.01 mM Fe(II)/g of extract). Antipyretic studies revealed that ethanol rootand leaf extracts at a dosage of 400 mg/kg in rats reducedthe pyrexia induced by Brewer’s yeast by 68.0 and 57.4%,respectively. Thus, nutraceutical potential of L. interruptaand ethnobotanical information about its use as anantipyretic was confirmed.
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Kasipandi Muniyandi,Gayathri Jagadeesan,Blassan P. George,Ashwini Lydia Manoharan,Gayathri Nataraj,Heidi Abrahamse,Parimelazhagan Thangaraj 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.13
A rich source of nutrients, figs have a number of clinically validated benefits. This study aimed to evaluate the in vitro simulated gastrointestinal digestion, and the antidiabetic and anticancer activity of Ficus microcarpa (FMP) and F. racemosa (FRP) fruits polysaccharides. The pre-digested FMP revealed higher sugar content (721 ± 14.81 mg glucose equivalents/g sample) than FRP. After in vitro digestion, isolated fruit polysaccharides showed effective uptake with over 80% sugar loss. Free radicals and enzymatic inhibition after gastric digestion have been significantly modified, demonstrating the effective absorption of FMP and FRP through the intestine. Conversely, after the continuous digestion, the nutritional content of the isolated polysaccharides was gradually decreased compared to the pre-digested sample. At 30 µg/mL concentration of FMP and FRP was inhibited by 50% of breast cancer cells. The present study reveals the potential uptake of FMP and FRP as nutritional supplements in the future.
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