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Tara Sunderland,John G. Kelly,Zebunnissa Ramtoola 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
The aim of this study was to evaluate a novel3-fluid concentric nozzle (3-N) spray drying process for themicroencapsulation of omeprazole sodium (OME) usingEudragit L100 (EL100). Feed solutions containing OMEand/or EL100 in ethanol were assessed visually for OMEstability. Addition of OME solution to EL100 solutionresulted in precipitation of OME followed by degradationof OME reflected by a colour change from colourless topurple and brown. This was related to the low pH of 2.8 ofthe EL100 solution at which OME is unstable. Precipitationand progressive discoloration of the 2-fluid nozzle (2-N)feed solution was observed over the spray drying timecourse. In contrast, 3-N solutions of EL100 or OME inethanol were stable over the spray drying period. Microparticlesprepared using either nozzle showed similarcharacteristics and outer morphology however the internalmorphology was different. DSC showed a homogenousmatrix of drug and polymer for 2-N microparticles while3-N microparticles had defined drug and polymer regionsdistributed as core and coat. The results of this studydemonstrate that the novel 3-N spray drying process canallow the microencapsulation of a drug using an incompatiblepolymer and maintain the drug and polymer inseparate regions of the microparticles.