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Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms
Ravisha Wadhwa,Divya Vohora,Manoj Kumar,Sushama Talegaonkar 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.2
Selective serotonin reuptake inhibitors (SSRIs) are currently the treatment of choice in depression and constitute major portion of prescription in depressive patients. The role of serotonin receptors in bone is emerging, raising certain questions regarding the effect of blockade of serotonin reuptake in the bone metabolism. Clinical studies have reported an association of SSRI antidepressants which with increase in fracture and decrease in bone mineral density. This review focus on recent evidence that evaluate the association of SSRIs with the risk of fracture and bone mineral density and also the probable mechanisms that might be involved in such effects.
Reddy, K.,Rao, S.,Inti, R.,Young, B.,Elshazly, A.,Talegaonkar, M.,Hanumolu, P. K. IEEE 2012 IEEE journal of solid-state circuits Vol.47 No.12
<P>This paper presents a continuous-time (CT) ΔΣ modulator using a VCO-based internal quantizer. It incorporates a nonlinear VCO as the second stage in a two-stage residue canceling quantizer (RCQ) and mitigates the impact of its nonlinearity by spanning only a small region of the VCO's V-to-F nonlinear tuning curve. The order of noise shaping is increased by placing the RCQ in a continuous-time ΔΣ loop. Using only a first order loop filter, the proposed ΔΣ modulator achieves second order noise shaping. Fabricated in a 90-nm CMOS process, the prototype modulator occupies an active area of 0.36 mm<SUP>2</SUP> and consumes 16 mW power. It achieves a peak SNDR of 78.3 dB in 10-MHz bandwidth and an SFDR of better than 85 dB when clocked at 600 MHz. The figure of merit of the modulator is 120 fJ/conv-step.</P>