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Shinji Hiyama,Toshie Sugiyama,Seiji Kusuhara,Takashi Uchida 대한수의학회 2012 JOURNAL OF VETERINARY SCIENCE Vol.13 No.3
The temporal expression of estrogen receptor (ER)α and ERβ mRNA was examined in male Japanese quails. Femurs of quails receiving 17βestradiol underwent RTPCR and histochemical analysis 1 to 15 days after treatment. Untreated quails were used as controls (day 0). Between days 0 and 5, cells lining the bone endosteal surface differentiated into osteoblasts, which in turn formed medullary bone. Expression of ERα was already observed on day 0 and increased slightly during bone formation whereas ERβ was hardly detected throughout this process. After osteoclasts appeared on the medullary bone surface, this type of bone disappeared from the bone marrow cavity (days 7∼15). ERα expression simultaneously decreased slightly and ERβ levels remained very low. These results suggest that estrogen activity mediated by ERα not only affects medullary bone formation but also bone resorption.
Design and Synthesis of Resin-Conjugated Tamiflu Analogs for Affinity Chromatography
Yasuaki Kimura,Kenzo Yamatsugu,Motomu Kanai,Noriko Echigo,Takashi Kusuhara,Masakatsu Shibasaki 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.3
Two types of resin-conjugated Tamiflu analogs were synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resins bound to influenza virus neuraminidase, the main target of Tamiflu. The resins will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the rarely observed abnormal behavior exhibited by some influenza patients treated with Tamiflu