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RISS 인기검색어
- 검색키워드
- 저자 : Surendra Patel (검색결과 2 건)
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Therapeutic potential of quercetin as a cardiovascular agent
Patel, Rahul V.,Mistry, Bhupendra M.,Shinde, Surendra K.,Syed, Riyaz,Singh, Vijay,Shin, Han-Seung Elsevier 2018 European journal of medicinal chemistry Vol.155 No.-
<P><B>Abstract</B></P> <P>Flavonoids are integral components of various vegetation and in foods; consequently, they represent an inevitable part of the diet. Historical and epidemiological proof recommend that diet plans consisting of flavonoids such as quercetin have positive health benefits, especially on the heart. Flavonoids have been proven to be active against hypertension, inflammation, diabetes and vascular diseases. Quercetin exhibits significant heart related benefits as inhibition of LDL oxidation, endothelium-independent vasodilator effects, reduction of adhesion molecules and other inflammatory markers, the protective effect on nitric oxide and endothelial function under conditions of oxidative stress, prevention of neuronal oxidative and inflammatory damage and platelet antiaggregant effects. Searching for experimental evidence to validate the cardioprotective effects of quercetin, we review here the recent detailed <I>in vivo</I> studies. Quercetin and its derivatives lead to an enhancement in heart features, indicating the prospective for quercetin to be used therapeutically in the treatment of cardiac diseases. Several evidence-based studies suggest mechanisms to observe cardiovascular diseases such as aging effects, hypertension, angiotensin-converting enzyme activity and endothelial-dependent and independent functions. Different animal models including human are also used to elucidate the <I>in vivo</I> role of quercetin in cardiovascular diseases. The role of quercetin and its derivatives may go beyond their existence in food and has potential as a lead molecule in drug development programs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Quercetin is a popular dietary anti-oxidant present in numerous vegetables and fruits, tea, and wine. </LI> <LI> Chemically, quercetin is a kind of flavonoid that particularly belongs to the flavonols group. </LI> <LI> The numerous cardioprotective activities of quercetin has been discussed. </LI> <LI> Quercetin protects against atherosclerosis, oxidative stress, cardiotoxicity, endothelial cell dysfunction, heart failure etc. </LI> <LI> Quercetin has potential as a lead molecule in drug development programs for cardiovascular diseases. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P> <I>In vivo</I> evidences for the cardio-protective functions of a natural compound quercetin have been reviewed.</P> <P>[DISPLAY OMISSION]</P>
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Cascade of Complications Following Carotid Body Tumor Excision
Pawan K Garg,Sarbesh Tiwari,Tushar S Ghosh,Surendra Patel,Ankur Sharma,Pushpinder S Khera 대한신경중재치료의학회 2021 Neurointervention Vol.16 No.3
Carotid body tumor excision can lead to various complications including vascular injury and pseudoaneurysm formation. Here we describe a case of carotid body tumor excision followed by series of complications including pseudoaneurysm formation, failure of primary surgical repair, carotid stump syndrome following parent artery occlusion, and persistent hypotension.
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