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박경근,Park, K.,Sonntag, R.E. 대한설비공학회 1995 설비공학 논문집 Vol.7 No.1
The objective of this work is to investigate the form of equations of state for specific refrigerants. In particular, equations of the extended van der Waals form have been studied. As a result, a new equation of state has been developed and tested over ranges of pressure and density up to 5 and 1.5 times critical, respectively. The equation of state separates the compressibility factor into two parts. One is the repulsive compressibility factor and the other is attractive. The former is in the same form of Carnahan-Starling's repulsive term with constant hard-sphere volume. The latter is based on a combination of two different functions linear to density. The equation of state developed here has 12 adjustable parameters and correlates PVT data successfully. All properties are in reduced forms.
( Yong Woo Lee ),( Hyung Joon Cho ),( Won Hee Lee ),( William E. Sonntag ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.4
Radiation therapy, the most commonly used for the treatment of brain tumors, has been shown to be of major signifi cance in tumor control and survival rate of brain tumor patients. About 200,000 patients with brain tumor are treated with either partial large fi eld or whole brain radiation every year in the United States. The use of radiation therapy for treatment of brain tumors, however, may lead to devastating functional defi cits in brain several months to years after treatment. In particular, whole brain radiation therapy results in a signifi cant reduction in learning and memory in brain tumor patients as long-term consequences of treatment. Although a number of in vitro and in vivo studies have demonstrated the pathogenesis of radiation-mediated brain injury, the cellular and molecular mechanisms by which radiation induces damage to normal tissue in brain remain largely unknown. Therefore, this review focuses on the pathophysiological mechanisms of whole brain radiation-induced cognitive impairment and the identifi cation of novel therapeutic targets. Specifi cally, we review the current knowledge about the effects of whole brain radiation on pro-oxidative and pro-infl ammatory pathways, matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) system and extracellular matrix (ECM), and physiological angiogenesis in brain. These studies may provide a foundation for defi ning a new cellular and molecular basis related to the etiology of cognitive impairment that occurs among patients in response to whole brain radiation therapy. It may also lead to new opportunities for therapeutic interventions for brain tumor patients who are undergoing whole brain radiation therapy.