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Daisuke Takahari,Keitaro Shimozaki,Izuma Nakayama,Kengo Nagashima,Koichiro Yoshino,Koshiro Fukuda,Shota Fukuoka,Hiroki Osumi,Mariko Ogura,Takeru Wakatsuki,Akira Ooki,Eiji Shinozaki,Keisho Chin,Kensei 대한위암학회 2023 Journal of gastric cancer Vol.23 No.4
Purpose: Determination of optimal treatment strategies for HER2-positive advanced gastric cancer (AGC) in randomized trials is necessary despite difficulties in direct comparison between trastuzumab deruxtecan (T-DXd) and nivolumab as third or later-line treatments. Materials and Methods: This single-institution, retrospective study aimed to describe the real-world efficacy and safety of T-DXd and nivolumab as ≥ third line treatments for HER2-positive AGC between March 2016 and May 2022. Overall, 58 patients (median age, 64 years; 69% male) were eligible for the study (T-DXd group, n=20; nivolumab group, n=38). Results: Most patients exhibited a HER2 3+ status (72%) and presented metastatic disease at diagnosis (66%). The response rates of 41 patients with measurable lesions in the T-DXd and nivolumab groups were 50% and 15%, respectively. The T-DXd and nivolumab groups had a median progression-free survival of 4.8 months (95% confidence interval [CI], 3.3, 7.0) and 2.3 months (95% CI, 1.5, 3.5), median overall survival (OS) of 10.8 months (95% CI, 6.9, 23.8) and 11.7 months (95% CI, 7.6, 17.1), and grade 3 or greater adverse event rates of 50% and 2%, respectively. Overall, 64% patients received subsequent treatment. Among 23 patients who received both regimens, the T-DXd–nivolumab and nivolumab–T-DXd groups had a median OS of 14.0 months (95% CI, 5.0, not reached) and 19.3 months (95% CI, 9.5, 25.1), respectively. Conclusions: T-DXd and nivolumab showed distinct efficacy and toxicity profiles as ≥ third line treatments for HER2-positive AGC. Considering the distinct features of each regimen, they may help clinicians personalize optimal treatment approaches for these patients.
2元系反應擴散における異相界面移動に關する 界面反應と局所平衡
李贊揆,尹在弘,下崎敏唯,大西正已 창원대학교 공작기계기술연구센터 1999 연구업적집 Vol.1 No.1
A moving phase boundary under the influence of binary reaction diffusion has been represented by the following flux equation; (Ji)αβ- (Ji)βα =-[(Ci)αβ-(Ci)βα]υ. If Ji is identical with the flux defined by Fick's first law, the boundary never moves. Other types except the Fick's flux, i.e., the fluxes relative to the phase boundary are introduced. Interfacial reaction and a local equilibrium state as non-equilibrium phenomena are discussed from the stand point of the flux balance at the phase boundary, Usually, interfacial reaction causes the boundary migration controlled by diffusion. The migration depends on the magnitude of a free energy difference developed at the boundary. As a special case the boundary moves under the existence of a local equilibrium state at the boundary without the interfacial reaction. The movement at the state arises from the Kirkendall effect.
Characteristic X-ray Spectrum Analysis of Micro-Sized SiC
Miyoshi, Noriko,Mao, Weiji,Era, Hidenori,Shimozaki, Toshitada,Shinozaki, Nobuya Korean Society of Microscopy 2016 Applied microscopy Vol.46 No.1
It has been investigated what kind of characteristic X-ray in electron probe micro-analyzer (EPMA) is effective for the determination of compounds of Si series materials. After comparing the characteristic X-rays among the primary and secondary lines in $K_{\alpha}$ and $K_{\beta}$ obtained from the Si series standard samples, it was found that the secondary line of $K_{\alpha}$ exhibited the most informative spectrum although the intensity was considerably weak. As a result of analyzing the spectrum shapes of the Si series standard samples, the spectrum shape of the secondary line of $K_{\alpha}$ for SiC was different from those for other Si compounds. To grasp the characteristics of the shape, a line was perpendicularly drawn from the peak top to base line in order to divide a spectrum into two areas. The area ratio of right to left was defined to call as the asymmetry index here. As a result, the asymmetry index value of the SiC was greater than one, while those of other Si compounds were less than one. It was found from the EPMA analysis that identification of SiC became successful to distinguish from other Si compounds and this method was applicable for micro-sized compounds in a practical composite material.
Magnetic Properties of Fe-Pt Films Electrodeposited by Diffusion Control
( Fei Li ),( Tae Hoon Kim ),( Bon Heun Koo ),( Chan Gyu Lee ),( Toshitada Shimozaki ) 대한금속재료학회 ( 구 대한금속학회 ) 2008 ELECTRONIC MATERIALS LETTERS Vol.4 No.3
Fe-Pt films were produced by a simple method of electrodeposition under diffusion control, using a novel bath system containing small amounts of Fe2+ and PtCl6(2-). The films were annealed and, their structure and magnetic properties were studied. The sample started to show some ordering at a temperature less than 550°C, which is lower than the previously reported ordering temperature. A coercivity of 3.2 kOe, comparable to previous data, and a squareness of 0.7 were obtained after the film was vacuum-annealed at 550°C for 15 min. The films displayed a longitudinal magnetic anisotropy. The obtained results promise this method to be a new choice for electrodeposition of Fe-Pt films.
Deformation Behavior of Corrosion-Resistant Fe-Cr Alloy
Era, Hidenori,Kono, Yusuke,Sasabuchi, Ryota,Miyoshi, Noriko,Tokunaga, Tatsuya,Shinozaki, Nobuya,Lee, Je-Hyun,Shimozaki, Toshitada Korean Society of Microscopy 2016 Applied microscopy Vol.46 No.1
Iron containing a high amount of chromium is known to be inferior to ductility due to ${\sigma}$ phase formation so that it is generally difficult to apply the plastic deformation process although the alloy possesses a superior characteristics of an excellent corrosion resistance. In this study, Fe-50mass%Cr alloy was melted using high purity powder and the deformation behavior has been investigated by cold rolling and tensile test. The tensile test yielded that the alloy revealed a serration at an early stage of tensile deformation and then the serrated flow vanished to change to a normal work hardening flow at the later stage. The former was governed by twin formation process, the latter by dislocation multiplication one, bringing about a high ductility of 20% or over. The reduction ratio in cold rolling was attained as high as 90%, thus the high corrosion-resistant alloy is able to possess a high ductility.