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- 저자 : Shashi Bala (검색결과 3 건)
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Total Ionization Dose (TID) Effects on 2D MOS Devices
Shashi Bala,Raj Kumar,Arvind Kumar 한국전기전자재료학회 2021 Transactions on Electrical and Electronic Material Vol.22 No.1
Electronics and Electricals devices are used in radiations environments for space applications. Radiation has immense potential to disturb the basic properties of electronics devices by interfere with the devices. Radiations aff ect most MOSFET among the various electronics devices, by creating radiation induced total ionizing dose (TID) effects, single event eff ects and heavy ion displacement damages, will be discussed. TID effects are persuaded due to ionization energy established in oxides and insulators existing in the devices, by electrons, charged hadrons, neutrons and gammas, prominent to device degradation and letdown. This paper reviews, the basic mechanism of TID in SiO2 and other alternate oxides in device and how, this affects threshold voltage, Sub threshold swing and leakage current in MOSFETs. Radiations response to the silicon-on-insulator technology will also be discussed.
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Rapid injuries of high temperature in plants
Gurpreet Kaur Goraya,Balraj Kaur,Bavita Asthir,Shashi Bala,Gurpreet Kaur Goraya,Muhammad Farooq 한국식물학회 2017 Journal of Plant Biology Vol.60 No.4
Global climate changes particularly high temperature is predicted to have a general negative effect on plant growth and development, that might lead to catastrophic loss of crop productivity. High temperature has a wide range of effect on plant in terms of plant physiological, biochemical processes such as photosynthesis, respiration water relations, and gene regulatory pathways. The injury inflicted on plant tissues under such extremes weakens the cell membrane, which leads to the production of reactive oxygen species that attacks major sites i.e photosynthetic apparatus, the photosystems, mainly photosystem II (PSII) and the respiratory pathways. To cope with rising temperature conditions, plants possess a number of adaptive, avoidance, or acclimation mechanisms. In addition to major tolerance mechanisms, plants also employ ion transporters, proteins, osmoprotectants, antioxidants and many other factors involved in signaling cascades and transcriptional control that are activated to offset stress-induced biochemical and physiological alterations. This article reviews the recent findings on high temperature induced injuries and responses at the cellular, organellar and whole plant levels.
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CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease
Poojitha Pinjala,Kamatham Pushpa Tryphena,Renuka Prasad,Dharmendra Kumar Khatri,선웅,Shashi Bala Singh,Dalapathi Gugulothu,Saurabh Srivastava,Lalitkumar Vora 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to correct the causative gene mutation and establish animal models in neurodegenerative disorders. Since no strategy developed until now could completely cure Parkinson’s disease (PD), neuroscientists aspire to use gene editing technology, especially CRISPR/Cas9, to induce a permanent correction in genetic PD patients expressing mutated genes. Over the years, our understanding of stem cell biology has improved. Scientists have developed personalized cell therapy using CRISPR/Cas9 to edit embryonic and patient-derived stem cells ex-vivo. This review details the importance of CRISPR/Cas9-based stem cell therapy in Parkinson’s disease in developing PD disease models and developing therapeutic strategies after elucidating the possible pathophysiological mechanisms.
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