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Production of Hydrogen and Carbon Nanotubes from Methane
Zein, Sharif Hussein Sharif,Mohamed, Abdul Rahman,Sai, P. Sesha Talpa,Zabidi, Noor Asmawati Mohd 한국공업화학회 2004 Journal of Industrial and Engineering Chemistry Vol.10 No.6
The decomposition of methane to produce hydrogen and carbon has been investigated experimentally using 15 ㏖% M/20 ㏖% NiO/TiO₂catalysts (where M = MnO_x, FeO, CoO, and CuO). The physical properties of these catalysts were obtained and their performances were evaluated for the conversion of methane and the CO and hydrogen yields. These catalysts were used in the experiments without any pretreatment. XRD patterns and TEM images of these catalysts show the morphological changes that are due to dopant addition. The results indicate the remarkable influence on the catalytic activity provided by doping. While different types of filamentous carbons are formed on the various Ni-containing catalysts, attractive carbon nanotubes were observed on the Mn/Ni/TiO₂-based catalyst. TEM studies on the used catalyst suggest that its stability depends on growth rate and the morphological structure of the formed carbon.
Sharif Yassin,Noa Sori,Ophir Gilad,Mati Shnell,Relly Richer,Nir Bar,Yishai Ron,Nathaniel Aviv Cohen,Subhi Abu-Abeid,Danit Dayan,Shai Meron Eldar,Shira Zelber-Sagi,Sigal Fishman 소화기인터벤션의학회 2024 International journal of gastrointestinal interven Vol.13 No.1
Background: Functional bowel disorders (FBDs), including irritable bowel syndrome (IBS), are common worldwide. Recently, increasingly many bariatric surgical procedures have been performed in response to rising obesity rates. However, data on the association between FBDs and bariatric surgery are scarce. We examined the prevalence of FBDs among candidates for bariatric surgery and prospectively investigated the association between FBDs and bariatric surgery. Methods: This prospective cohort study included 112 bariatric surgery candidates at the Tel Aviv Medical Center from 2019 to 2020. Before and after surgery, patients completed the Rome III questionnaire. Data regarding demographics, socioeconomic status, and gastrointestinal symptoms were recorded. The rates of FBDs—IBS, functional constipation (FC), functional diarrhea (FDi), and unspecified functional bowel disorder (UFBD)—were then compared from before surgery to 6 months after the procedure. Results: Of 112 candidates with obesity at baseline, 68 underwent surgery and completed the postoperative questionnaire. Overall, the respective prevalence rates of FBDs, IBS, FC, FDi, and UFBD were 37.5%, 2.7%, 17.9%, 5.4%, and 11.6%. Female sex and single status were particularly common among patients with FBDs, whereas divorced status was more frequent in the group without FBDs. However, these factors were not independently associated with FBD presence upon multivariable analysis. IBS was more prevalent after surgery than before (8.8% vs. 1.5%, P = 0.06), but FBDs in general did not share this trend (44.1% vs. 36.8%, P = 0.44). Conclusion: Bariatric surgery appears to increase the risk of developing IBS, while not impacting the overall risk of FBDs.
N-Acetyl-D-Glucosamine Kinase Interacts with Dynein-Lis1-NudE1 Complex and Regulates Cell Division
Sharif, Syeda Ridita,Islam, Md. Ariful,Moon, Il Soo Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.9
N-acetyl-D-glucosamine kinase (GlcNAc kinase or NAGK) primarily catalyzes phosphoryl transfer to GlcNAc during amino sugar metabolism. Recently, it was shown NAGK interacts with dynein light chain roadblock type 1 (DYNLRB1) and upregulates axo-dendritic growth, which is an enzyme activity-independent, non-canonical structural role. The authors examined the distributions of NAGK and NAGK-dynein complexes during the cell cycle in HEK293T cells. NAGK was expressed throughout different stages of cell division and immunocytochemistry (ICC) showed NAGK was localized at nuclear envelope, spindle microtubules (MTs), and kinetochores (KTs). A proximity ligation assay (PLA) for NAGK and DYNLRB1 revealed NAGK-dynein complex on nuclear envelopes in prophase cells and on chromosomes in metaphase cells. NAGK-DYNLRB1 PLA followed by Lis1/NudE1 immunostaining showed NAGK-dynein complexes were colocalized with Lis1 and NudE1 signals, and PLA for NAGK-Lis1 showed similar signal patterns, suggesting a functional link between NAGK and dynein-Lis1 complex. Subsequently, NAGK-dynein complexes were found in KTs and on nuclear membranes where KTs were marked with CENP-B ICC and nuclear membrane with lamin ICC. Furthermore, knockdown of NAGK by small hairpin (sh) RNA was found to delay cell division. These results indicate that the NAGK-dynein interaction with the involvements of Lis1 and NudE1 plays an important role in prophase nuclear envelope breakdown (NEB) and metaphase MT-KT attachment during eukaryotic cell division.
Sharif, Naubahar,Ritter, Waltraut,Davidson, Robert L,Edmunds, Scott C World Association for Triple Helix and Future Stra 2018 Journal of Contemporary Eastern Asia Vol.17 No.2
Open Science is an umbrella term that involves various movements aiming to remove the barriers to sharing any kind of output, resources, methods or tools at any stage of the research process. While the study of open science is relatively advanced in Western countries, we know of no scholarship that attempts to understand open science in Hong Kong. This paper provides a broad-based background on the major research data management organisations, policies and institutions with the intention of laying a foundation for more rigorous future research that quantifies the benefits of open access and open data policies. We explore the status and prospects for open science (open access and open data) in the context of Hong Kong and how open science can contribute to innovation in Hong Kong. Surveying Hong Kong's policies and players, we identify both lost research potential and provide positive examples of Hong Kong's contribution to scientific research. Finally, we offer suggestions regarding what changes can be made to address the gaps we identify.
N-Acetyl-D-Glucosamine Kinase Is a Component of Nuclear Speckles and Paraspeckles
Sharif, Syeda Ridita,Lee, HyunSook,Islam, Md. Ariful,Seog, Dae-Hyun,Moon, Il Soo Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.5
Protein O-GlcNAcylation, dictated by cellular UDP-N-acetylglucosamine (UDP-GlcNAc) levels, plays a crucial role in posttranslational modifications. The enzyme GlcNAc kinase (NAGK, E.C. 2.7.1.59) catalyzes the formation of GlcNAc-6-phosphate, which is a major substrate for the biosynthesis of UDP-GlcNAc. Recent studies have revealed the expression of NAGK in different types of cells especially in neuronal dendrites. Here, by immunocytochemistry (ICC) and immunonucleochemistry (INC) of cultured rat hippocampal neurons, HEK293T and GT1-7 cells, we have showed that NAGK immuno-reactive punctae being present in the nucleoplasm colocalized with small nuclear ribonucleoprotein-associated protein N (snRNPN) and p54NRB, which are speckle and paraspeckle markers, respectively. Furthermore, NAGK IR cluster was also found to be colocalized with GTF2H5 (general transcription factor IIH, polypeptide 5) immuno reactive punctae. In addition, relative localization to the ring of nuclear lamin matrix and to GlcNAc, which is highly enriched in nuclear pore complexes, showed that NAGK surrounds the nucleus at the cytoplasmic face of the nuclear outer membrane. By in situ proximity ligation assay (PLA) we confirmed the colocalization of NAGK with snRNPN in the nucleus and in dendrites, while we also verified the interactions of NAGK with p54NRB, and with GTF2H5 in the nucleus. These associations between NAGK with speckle, paraspeckle and general transcription factor suggest its regulatory roles in gene expression.
Lipoxygenase Inhibitory Constituents from Indigofera oblongifolia
Sharif, Ahsan,Ahmed, Ejaz,Malik, Abdul,Riaz, Naheed,Afza, Nighat,Nawaz, Sarfraz Ahmad,Arshad, Muhammad,Shah, Muhammad Raza,Chaudhary, Muhammad Iqbal The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.7
Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with $\beta$-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.
A physically consistent stress-strain model for actively confined concrete
Sharif Shahbeyk,Mahshid Z. Moghaddam,Mohammad Safarnejad 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.20 No.1
With a special attention to the different stages of a typical loading path travelled in a fluid confined concrete test, this paper introduces a physically consistent model for the stress-strain curve of actively confined normal-strength concrete in the axial direction. The model comprises of the five elements of: (1) a criterion for the peak or failure strength, (2) an equation for the peak strain, (3) a backbone hydrostatic curve, (4) a transient hardening curve linking the point of departure from the hydrostatic curve to the failure point, and finally (5) a set of formulas for the post-peak region. Alongside, relevant details and shortcomings of existing models will be discussed in each part. Finally, the accuracy and efficiency of the proposed model have been verified in a set of simulations which compare well with the experimental results from the literature.
Sharif, Sumaira,Shahid, Muhammad,Mushtaq, Muhammad,Akram, Sumia,Rashid, Ayoub The Korean Society of Food Science and Nutrition 2017 Preventive Nutrition and Food Science Vol.22 No.2
This paper describes in detail proximate composition, nutritional profile, phytochemical constituents, antioxidant activities, antimicrobial potential, and antihemolytic activity (towards human erythrocytes) of various fractions of wild Ganoderma lucidum. Proximate analysis established that wild G. lucidum comprises about $87.02{\pm}5.45%$ of moisture, and the remaining part is a rich source of proteins ($8.59{\pm}0.37%$), crude fiber ($54.21{\pm}1.2%$), and carbohydrate (35.16%) with smaller fat content (3.33 %). Similarly, phytochemical screening revealed the presence of flavonoids ($217.51{\pm}0.30mg/g$), ascorbic acid ($116{\pm}7.32mg/g$), phenolics ($360.72{\pm}34.07mg/g$), ${\beta}$-carotenes ($0.42{\pm}0.04{\mu}g/g$), and lycopene ($0.05{\pm}0.00{\mu}g/g$). Extracts of wild G. lucidum in various solvents provided first line protection against Escherichia coli and Pasteurella multocida in the order of ethyl acetate> ethanol> methanol> n-hexane> water. Furthermore, aqueous and methanolic extracts of wild G. lucidum were found to be safe towards human erythrocytes. Overall, wild mushroom (G. lucidum) was found to be a good source of dietary supplements, antimicrobial and antioxidant agents in the pursuance of its commercial utilization in food and pharmaceutical industries.