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Sayan Basak 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.5
Multistimuli-Responsive Nanogels are one of the most trending materials in the scope of biomedical science, which responds when excited with a range of stimuli including temperature, pH, UV light, and redox chemical moieties. These ‘smart’ nanomaterials are reported to exhibit not only higher drug/cargo release profiles, but also enhance the specificity of target delivery. This perspective aims to circumscribe the Author’s viewpoint of how these Multistimuli-Responsive Nanogels are gradually evolving and metamorphosing the biomedical sector (drug delivery, tissue engineering, gene delivery, bio-sensors, bioimaging, cell culture systems, and bio-inspired operations) with supplements from the fascinating developments in the realms of material science and nanotechnology.
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Co-evolving with Nature: The Recent Trends on the Mussel-inspired Polymers in Medical Adhesion
Sayan Basak 한국생물공학회 2021 Biotechnology and Bioprocess Engineering Vol.26 No.1
The rise in the number of daily surgical procedures and the disadvantages posed by the present surgical closure techniques (such as secondary tissue damage and microbial infection) magnifies the immediate need for metamorphosing the current bioadhesives perceiving to tether wounds efficiently. To this context, the emerging scope of biomimetics has allowed mussel inspired adhesives rendering efficient bonding characteristics on a variety of substrates. The mussel adhesion proteins and its derivatives, such as 3,4-dihydroxyphenylalanine and dopamine, are therefore widely being studied to modify the biopolymers, attempting to enhance the adhesive attributes. The polarity of the catechol groups in the protein conformation aids in the development of both noncovalent interactions (electrostatic interaction, hydrogen bonding, metal/ligand coordination bond, π–π/cation-π interactions) and covalent interactions (crosslinking), thereby promoting superior tissue adhesion. This narrative is an attempt to tether the recent developments in the mussel-inspired polymer adhesives, connecting the footprints of how these materials evolved with its current state of the art.
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