http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
오늘 본 자료
Addition Reaction of Cyclopropane with Magnesium Dihydride (MgH<sub>2</sub>): A Theoretical Study
Singh, Satya Prakash,Meena, Jay Singh,Thankachan, Pompozhi Protasis Korean Chemical Society 2013 대한화학회지 Vol.57 No.6
The addition reaction of cyclopropane with $MgH_2$ has been investigated using the B3LYP density functional method employing several split-valence basis sets. Both along the and perpendicular to the cyclopropane ring approach has been reported. It is shown that the reaction proceeds via a four-centered transition state. Calculations at higher levels of theory were also performed at the geometries optimized at the B3LYP level, but only slight changes in the barriers were observed. Structural parameters for the transition state are also reported.
Theoretical Study of the Hydroalumination Reaction of Cyclopropane with Alane
Singh, Satya Prakash,Thankachan, Pompozhi Protasis Korean Chemical Society 2013 대한화학회지 Vol.57 No.2
The hydroalumination of cyclopropane has been investigated using the B3LYP density functional method employing several split-valence basis sets. It is shown that the reaction proceeds via an intermediate weakly bound complex and a four-centered transition state. Calculations at higher levels of theory were also performed at the geometries optimized at the B3LYP level, but only slight changes in the barriers were observed. Structural parameters for the transition state are also reported.
Abdul Qadir,Muhammad Arif,Satya Prakash Singh,Juber Akhtar,Athar Ali 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.1
The date seeds oil is a mixture of different types of major and minor organic components with potential positive health benefits. Thus, the study was designed to conversion of Ajwa verity of Saudi Arabian date seeds into pyrolysis liquid char oil by slow pyrolysis reactor and its phytoconstituents were determined by GC–MS. The date seed in particle form was pyrolysed in an externally heated pan sand bath. The sand bath was heated upto 500–600 °C by means of a burner for pyrolysis and this temperature is measured by means of a mercury thermometer. During pyrolysis, the tar and oil are released from the seeds and collected in a container. The liquid char oil was dissolved in 100 ml methanol and fractionated with 100 ml n-hexane by using separating funnel. Small portion (1 g) of both fraction was subjected to GC-MS analysis. GC-MS analysis results indicated the presence of 40 and 27 different phyto-compounds from n-hexane and methanol fraction. The presence of these bioactive compounds confirms the application of the Ajwa variety of date seeds for various medicinal activities in future drug discovery system and can be analyzed for anti-inflammatory, antioxidant, cardiovascular, anticancer and immunosuppressant activities.
Richa Srivastava,Sajal Srivastava,Satya Prakash Singh 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.1
This study was to prepare a novel in situ gel system for nasal delivery of poly-herbal extracts and study its efficacy on the allergic rhinitis model. The main purpose is to compare the efficacy of poly-herbal nasal drops and in situ gel. A temperature depended in situ gel was developed and characterized with gellan gum as a carrier. The system was stable kept at 40 ± 2 °C for 6 months, and the micrographic results showed that in situ gel was safety without mucous irritation when given daily for 26 days to mice with allergic rhinitis that the effect of drops for the treatment. Extracts in gellan gum produced obviously effect on allergic rhinitis at the doses of 20 g/body following intranasal administration, and the efficacy was significantly superior to that of the drops (p < 0.01). This study uses Kruskal–Wallis test analysis of variance (ANOVA) followed by Dunn’s test for the first time to develop, optimize the formulation and assess factors affecting the critical quality attributes. Histopathological study of the nasal mucosa suggested that the formulation was safe for nasal administration. The statistical difference in absolute bioavailability between drop and in situ gel by nasal route suggested that in situ gel had almost 21% increase in bioavailability for Moringa oleifera and for Embelia Ribes in combination there was a 16% increase over drop formulations. Thus the situ gel system is a promising approach for the intranasal delivery of polyherbal extracts for the therapeutic effect improvement.