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RISS 인기검색어
- 검색키워드
- 저자 : Sarika Gupta (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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TP53 Polymorphisms in Sporadic North Indian Breast Cancer Patients
Sharma, Sarika,Sambyal, Vasudha,Guleria, Kamlesh,Manjari, Mridu,Sudan, Meena,Uppal, Manjit Singh,Singh, Neeti Rajan,Bansal, Darpan,Gupta, Arun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Background: The purpose of this study was to evaluate the potential association of five (p.P47S, p.R72P, PIN3 Ins16bp, p.R213R and r.13494g>a) polymorphisms of TP53 with the risk of developing breast cancer in North Indian Punjabi population. Methods: We screened DNA samples of 200 sporadic breast cancer patients (197 females and 3 males) and 200 unrelated healthy, gender and age matched individuals for the polymorphisms. Results: For the p.P47S polymorphism, we observed the PP genotype in 99.5% of the patients and PS genotype in only 1 patient. All the controls had the wild type PP genotype. The frequency of RR, RP and PP genotype of p.R72P was 23.5% vs 33.5%, 51.5% vs 45.5% and 25% vs 21% in patients and controls respectively. Heterozygous (RP) genotype was increased in breast cancer patients as compared to controls (51.5 vs 45.5%) and showed 1.61 fold significantly increased risk for breast cancer (OR=1.61, 95% CI, 1.01-2.58, p=0.04). In breast cancer patients the frequencies of A1A1, A1A2 and A2A2 genotypes of PIN3 Ins16bp polymorphism were 67%, 26% and 7% respectively whereas in controls the genotype frequencies were 68.5%, 27.5% and 4% respectively, with no significant difference. For p.R213R (c.639A>G), all individuals had homozygous wild type genotype. The frequencies of GG, GA and AA genotypes of TP53 r.13494g>a polymorphism were 62 vs 67.5%, 33 vs 28% and 5 vs 4.5% in patients and controls respectively, again without significant difference. We observed that RP-A1A1 genotype combination of p.R72P and PIN3 Ins16bp and RP-GG combination of p.R72P and r.13494g>a polymorphism showed significant risk of breast cancer (OR=1.65, 95%CI: 0.98-2.78, p=0.05; OR=1.72, 95%CI: 1.01-2.92, p=0.04). Conclusion: The results of present study indicated that among the five TP53 polymorphisms investigated, the p.R72P polymorphism, and the RP-A1A1 and RP-GG genotype combination contribute to breast cancer susceptibility in North Indians.
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Oral Health of Stone Mine Workers of Jodhpur City, Rajasthan, India
Solanki, Jitender,Gupta, Sarika,Chand, Sachin Occupational Safety and Health Research Institute 2014 Safety and health at work Vol.5 No.3
Background: Occupational injuries cause major health problems, which the developed, developing, and underdeveloped nations worldwide are facing today. The present study aimed to assess dental caries, periodontal health of stone mine workers, and the relationship between wasting diseases and the years of working experience. Methods: The study population comprised 510 men, selected based on the stratified cluster sampling procedure. Clinical oral examinations were carried out, and periodontal disease, dental caries, and wasting diseases were recorded. Results: Workers were in the age group of 17-56 years; the prevalence of dental caries in the workers was found to be 74%, with a mean decayed, missing, filled teeth index of 2.89. A periodontal pocket of more than 6 mm was observed in 6% of the workers. Conclusion: The oral health of mine workers is in a poor state; steps should be taken so as to provide basic medical and dental care facilities.
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Oral Health of Stone Mine Workers of Jodhpur City, Rajasthan, India
Jitender Solanki,Sarika Gupta,Sachin Chand 한국산업안전보건공단 산업안전보건연구원 2014 Safety and health at work Vol.5 No.3
Background: Occupational injuries cause major health problems, which the developed, developing, andunderdeveloped nations worldwide are facing today. The present study aimed to assess dental caries,periodontal health of stone mine workers, and the relationship between wasting diseases and the yearsof working experience. Methods: The study population comprised 510 men, selected based on the stratified cluster samplingprocedure. Clinical oral examinations were carried out, and periodontal disease, dental caries, andwasting diseases were recorded. Results: Workers were in the age group of 17e56 years; the prevalence of dental caries in the workerswas found to be 74%, with a mean decayed, missing, filled teeth index of 2.89. A periodontal pocket ofmore than 6 mm was observed in 6% of the workers. Conclusion: The oral health of mine workers is in a poor state; steps should be taken so as to providebasic medical and dental care facilities.
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Munish Ashat,Kaartik Soota,Jagpal S. Klair,Sarika Gupta,Chris Jensen,Arvind R. Murali,Randhir Jesudoss,Rami El Abiad,Henning Gerke 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.4
Background/Aims: Endoscopic ultrasound (EUS)-guided fine-needle aspiration is very effective for providing specimens forcytological evaluation. However, the ability to provide sufficient tissue for histological evaluation has been challenging due to thetechnical limitations of dedicated core biopsy needles. Recently, a modified EUS needle has been introduced to obtain tissue coresamples for histological analysis. We aimed to determine (1) its ability to obtain specimens for histological assessment and (2) thediagnostic accuracy of EUS-guided fine-needle biopsy (EUS-FNB) using this needle. Methods: We retrospectively analyzed consecutive cases of FNB using modified EUS needles for 342 lesions in 303 patients. Thecytology and histological specimens were analyzed. Diagnostic accuracy was calculated. Results: Adequate cytological and histological assessment was possible in 293/342 (86%) and 264/342 (77%) lesions, respectively. Diagnostic accuracy of the cytological specimen was 294/342 (86%) versus 254/342 (74%) for the histological specimen (p<0.01). Diagnostic accuracy of the combined cytological and histological assessment was 323/342 (94.4%), which was significantly higher thanthat of both histology alone (p<0.001) and cytology alone (p=0.001). Conclusions: EUS-FNB with the modified EUS needle provided histologic tissue cores in the majority of cases and achieved excellentdiagnostic accuracy with few needle passes.
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