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Cho, Sang-Min,Choi, Hoo-Kyun The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.5
A mucoadhesive microsphere was prepared by an interpolymer complexation and solvent evaporation method, using chitosan and poly(acrylic acid) (PAA), to prolong the gastric resid ence time of the delivery system. The Fourier transform infrared results showed that microspheres were formed by an electrostatic interaction between the carboxyl groups of the PAA and the amine groups of the chitosan. X-ray diffraction and differential scanning calorimetry analysis showed that the enrofloxacin in the chitosan-PAA microsphere was molecularly dispersed in an amorphous state. Scanning electron microscopy of the surface and the quantity of mucin attached to the microspheres indicated that chitosan-PAA microspheres had a higher affinity for mucin than those of chitosan alone. The swelling and dissolution of the chitosan-PAA microspheres were found to be dependent on the pH of the medium. The rate of enrofloxacin released from the chitosan-PAA microspheres was slower at higher pH; therefore, based on their mucoadhesive properties and morphology, the chitosan-PAA microspheres can be used as a mucoadhesive oral drug delivery system.
Cho, Sang-Min,Choi, Hoo-Kyun 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2
Mucoadhesive microspheres were prepared by interpolymer complexation of chitosan with poly(acrylic acid) (PAA) and solvent evaporation method to increase gastric residence time. The chitosan-PAA complex formation was confirmed by differential scanning calorimetry and swelling study. The DSC thermogram of chitosan-PAA microspheres showed two exothermic peaks for the decomposition of chitosan and PAA. The swelling ratio of the chitosan-PAA micro-spheres was dependent on the pH of the medium. The swelling ratio was higher at pH 2.0 than at neutral pH. The results indicated that the microspheres were formed by electrostatic interaction between the carboxyl groups of PAA and the amine groups of chitosan. The effect of various process parameters on the formation and morphology of microspheres was investigated. The best microspheres were obtained when 1.5% of the high molecular weight chitosan and 0.3% of PAA were used as an internal phase. The optimum internal phase volume was 7%. The corn oil was used as the external phase of emulsion, and span 80 was used as the surfactant. The prepared microspheres had spherical shape.
Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue
Cho, Moon Kyun,An, Je Min,Kim, Chul Han,Kang, Sang Gue Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.1
Background Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. Methods Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. Results Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining. Conclusions Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
Sang Kyun Cho(趙湘均),Young Jin oh(吳永鎭),Sug Kee Suh(徐錫埼),Hak Sin Kim(金學信),Soo Dong Kim(金洙東),Young Sun Chang(張榮宣),Kyeong Gu Choi(崔京求) 한국육종학회 1995 한국육종학회지 Vol.27 No.2
Improvement of sprout soybeans could be accomplished by maintenance and collection of varieties which have characteristics of small seed, disease resistance and high yielding ability. This research was conducted to investigate morphological and ecological characters for 102 sprout soybean varieties collected in Chonnam and Chonbuk area, and donated by Sprout Soybean Association and Genetic Engineering Research Institute. The sprout soybean collections contained 85% purple flower color, 76% ring-type leaf, 68% brown trichome, 57% elliptical-type seed, 69% yellow seed color and 44% brown hilum color. Days to flowering ranged from 53 to 79 days and growth duration averaged 137 days, with the range of 119~149 days. Stem length ranged from 52㎝ to 165㎝ and 100-seed weight distributed into 4.9~13.3g. The grain yield revealed large range of 0.53~4.18MT/ha. Crude protein and lipid contents was ranged 35.8~48.7% (average 40.9%), and 19.1~’21.2% (average 20.1%), respectively. Correlation coefficients between grain yield and pod numbers was significantly positive, while that between 100-seed weight and pod numbers was significantly nagative. Crude protein contents was significantly associated with growth duration but negatively correlated with 100-seed weight and yield. Crude lipid contents was negatively correlated with growth duration but positively associated with 100-seed weight.
In vitro and in vivo mechanical stability of orthodontic mini-implants.
Cho, Il-Sik,Kim, Sung-Kyun,Chang, Young-Il,Baek, Seung-Hak Angle Orthodontists Research and Education Foundat 2012 The Angle orthodontist Vol.82 No.4
<P>To compare in vivo and in vitro mechanical stability of orthodontic mini-implants (OMIs) treated with a sandblasted, large-grit, and anodic-oxidation (SLAO) method vs those treated with a sandblasted, large-grit, and acid-etching (SLA) method.</P>
( Sung Eun Kim ),( Jae Yoon Jeong ),( Dae Won Jun ),( Eileen L. Yoon ),( Jae-jun Shim ),( Sang Bong Ahn ),( Yong Kyun Cho ),( Soung Won Jeong ),( Hyoung Su Kim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: We investigate the efficacy and safety of entecavir (ETV) versus tenofovir (TDF) in treatment-naïve chronic hepatitis B (CHB) patients with chronic kidney disease (CKD) in real life setting. Methods: A total of 1,349 naïve CHB patients treated with ETV or TDF at least 1 year in 9 academic hospitals from Jan. 2012 to Dec. 2015 were enrolled. Among them, 44 patients had CKD at enrollment. CKD was defined as glomerular filtration rate <60ml/min/1.73m2. Renal functional decline was defined when serum creatinine level increased by more than 50% from baseline or over than 0.3 mg/dL at 1 year Results: A total of 44 patients (ETV=30 and TDF 14) were followed up for a median 28 months. There were no significant differences in cumulative biochemical response rate and culmulative HBeAg seroconversion rate between the ETV group and the TDF group at weeks 12, 24, and 48 of treatment. However, there were significant differences in culmulative virologic response rate between the ETV group and the TDF group at weeks 12, 24, and 48 of treatment (14%/31%/55% vs.14%/64%/86%, P =0.022). Renal functional decline occurred in 13 (29.5%) patients. Renal functional decline showed no significant difference between the ETV group and TDF group (33% vs. 21%, P=0.420). In multivariate analysis, serum albumin was an independent factor associated with renal functional decline (odd ratio, 0.28; confidence interval, 0.08- 0.95; P=0.041). However, age, sex, BMI, DM, hypertention, baseline HBV-DNA level, HBeAg positivity, cirrhosis, baseline renal function, bilirubin level, platelet count, hemoglobin level, ascites and treatment regimen were not associated with renal functional decline in CHB patient with CKD. Conclusions: TDF had better clinical efficacy than ETV in CHB patient with CKD. This study suggests that close monitoring of renal function are required for CHB patients with CKD and low albuminemia who are receiving antiviral agents.
A Framework for Processing Brain Waves Used in a Brain-computer Interface
Sung, Yun-Sick,Cho, Kyun-Geun,Um, Ky-Hyun Korea Information Processing Society 2012 Journal of information processing systems Vol.8 No.2
Recently, methodologies for developing brain-computer interface (BCI) games using the BCI have been actively researched. The existing general framework for processing brain waves does not provide the functions required to develop BCI games. Thus, developing BCI games is difficult and requires a large amount of time. Effective BCI game development requires a BCI game framework. Therefore the BCI game framework should provide the functions to generate discrete values, events, and converted waves considering the difference between the brain waves of users and the BCIs of those. In this paper, BCI game frameworks for processing brain waves for BCI games are proposed. A variety of processes for converting brain waves to apply the measured brain waves to the games are also proposed. In an experiment the frameworks proposed were applied to a BCI game for visual perception training. Furthermore, it was verified that the time required for BCI game development was reduced when the framework proposed in the experiment was applied.