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- 저자 : S. Sanju (검색결과 2 건)
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S. Gokulkumar,Indran Suyambulingam,Divya Divakaran,G. Suganya Priyadharshini,M. Aravindh,Jenish Iyyadurai,M. Sanju Edwards,Suchart Siengchin 한국고분자학회 2023 Macromolecular Research Vol.31 No.12
Researchers are focusing their efforts on developing high-performance bio-based composites due to increased interest in the production of natural fiber-based polymer composites utilizing novel cellulosic fillers. The primary goal of this study is to comprehend physicochemical and morphological characteristics, crystallinity, and thermal behavior of Lantana aculeata leaf cellulose (LALC) fillers. The extracted cellulose has some unique properties, such as excellent mechanical properties, lower density, bio-compatibility, heat resistance, and processability. Using X-ray diffraction, crystallinity index and size of Lantana aculeata leaf cellulose were calculated to be 73.7 and 7.42 nm, respectively. Furthermore, the morphology of the extracted LALC filler was examined using Scanning Electron Microscopy (SEM) and ImageJ software, and its average size was determined to be 69.21 nm. In addition, Fourier-transform infrared spectroscopy (FTIR) revealed that the extracted LALC contained no other non-cellulosic components due to alkali treatment, as they isolate cellulose and minimize the presence of non-cellulosic components. Furthermore, atomic force microscopy (AFM) revealed that the surface roughness of the cellulose is less than 4.630 nm, paving the way for an agricultural residue to be transformed into a desirable cellulosic filler material for developing polymeric composites. It can also withstand temperatures of maximum up to 247.23 °C, making it a viable substitute for more traditional sources. It can be used in a variety of polymer composite applications, including packaging materials, automotive parts, and building materials.
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Extracellular Trap by Blood Cells: Clinical Implications
R. J. Nija,S. Sanju,Neeraj Sidharthan,Ullas Mony 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.2
BACKGROUND: Extracellular trap formation (ETosis) by various blood cells has been reported. This trap contains DNA, histones and granular proteins which can elicit an innate immune response by entrapping microorganisms. The trap thus formed has been reported to have an involvement in various pathogenic conditions as well. This review focusses on the trap formation by different blood cells, the immune response associated with trap formation and also its role in various clinical conditions. METHOD: An extensive literature survey on ETosis by blood cells from 2003 to 2019 has been done. After going through the literature throughly, in this review we focuses on the trap formation by different blood cell types such as neutrophils, macrophages, eosinophils, basophils, mast cells, plasmacytoid dentritic cells, and monocytes. The mechanism with which it releases trap, the immune response it elicits and ultimately its involvement in various pathogenic conditions are described here. This article extensively covered all the above aspects and finally comprehends in nutshell the various stimuli that are currently known in trigerring the ETosis, its effect and ultimately its role in disease process. RESULTS: A clarity about the extracellular trap formation by various blood cells, mechanism of ETosis, role of Etosis in microbial invasion and in various pathogenic situations by various blood cells have been described here. CONCLUSION: The current understanding about the process of ETosis and its effects has been extensively described here. Along with lot of favourable outcomes, the process of ETosis will lead to lot of pathogenic situations including thrombosis, tumour metastasis and sepsis. Current understanding about ETosis is limited. Indepth understanding of ETosis may have great therapeutic potential in the diagnosis, guiding of therapy and prognostication in various pathogenic situations including infectious conditions, autoimmune disorders and tumors.
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