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Assessment of Parenting Attitudes by Children and Adolescents with Migraine
Kyeong Mi Lee(Kyeong Mi Lee),Min Suk Koh(Min Suk Koh),Ho-chan Lim(Ho-chan Lim),Soorack Ryu(Soorack Ryu),Yong Joo Kim(Yong Joo Kim),Jin-Hwa Moon(Jin-Hwa Moon) 대한소아신경학회 2022 대한소아신경학회지 Vol.30 No.4
Purpose: We aimed to investigate the parenting attitudes reported by patients and their relationships with the characteristics of headaches in children and adolescents with migraine. Methods: We conducted a retrospective review of medical records of children and adolescents with migrainous headaches (n=115; 59.1% female; mean age, 11.89±2.00 years). Children evaluated parental attitudes using the Parenting Attitude Test-Youth (PAT-Y), which comprises eight subscales and four newly devised secondary subscales. Headache severity was calculated by the visual analog scale (VAS), monthly frequency (MF), and VAS×MF/4 (VF). The scores of PAT-Y subscales and the correlations between PAT-Y scores and headache severity were analyzed by age group and sex. Scores for children’s depression inventory, childhood behavior checklists, and an attention deficit hyperactivity disorder scale were also analyzed. Results: In the elementary school age group, VAS was weakly negatively correlated with the “achievement press” (r=-0.28, P<0.05) and “high expectation” (r=-0.25, P<0.05) attitudes, and VF was weakly negatively correlated with “achievement press” (r=-0.32, P<0.05), “punishment” (r=-0.27, P<0.05), and “high expectation” (r=-0.29, P<0.05). In the middle-school age group, MF and VF were moderately positively correlated with the “achievement press” attitude (r=0.48, P<0.01 and r=0.48, P<0.01, respectively), VF was weakly positively correlated with the “neglectful” attitude(r=0.31, P<0.05), and MF was weakly positively correlated with scores for depression (r=0.29, P<0.05) and internalized problems (r=0.31, P<0.05). Conclusion: Parenting attitudes perceived by children and adolescents with migrainous headaches varied by age, and some parenting attitudes were related to headache severity. Education on age-appropriate parenting attitudes may help cope with migrainous headaches.
Potential Anti-inflammatory Effects of the Fruits of <i>Paulownia tomentosa</i>
Ryu, Hyung Won,Park, Yhun Jung,Lee, Su Ui,Lee, Seoghyun,Yuk, Heung Joo,Seo, Kyeong-Hwa,Kim, Yeah-Un,Hwang, Bang Yeon,Oh, Sei-Ryang American Chemical Society and American Society of 2017 Journal of natural products Vol.80 No.10
<P>As part of an ongoing search for new natural products from medicinal plants to treat respiratory disease, six new compounds, a dihydroflavonol (1) and five C-geranylated flavanones (3, 6, 8, 13, and 14), and 13 known compounds were isolated from mature fruits of Paulownia tomentosa. The structures of the new compounds were determined via interpretation of their spectroscopic data (1D and 2D NMR, UV, IR, ECD, and MS). In biological activity assays with human alveolar basal epithelial cells, the expression of TNF-alpha-induced proinflammatory cytokines (IL-8 and IL-6) was reduced significantly by the EtOAc fraction of a P. tomentosa extract as well as by the new compounds isolated from this fraction. Furthermore, the majority of the isolates (1-19 except 5-7) were found to inhibit human neutrophil elastase (HNE) activity, with IC50 values ranging from 2.4 +/- 1.0 to 74.7 +/- 8.5 mu M. In kinetic enzymatic assays with the HNE substrate MeOSuc-AAPV-pNA, compound 17 exhibited the highest inhibitory activity (K-i = 3.2 mu M) via noncompetitive inhibition. These findings suggest that the flavanone constituents of P. tomentosa fruits may be valuable for the development of new drug candidates to treat airway inflammation.</P>
변색기 고온에 의한 ‘거봉’ 및 ‘흑보석’ 포도의 과피 안토시아닌 조성 변화
류수현(Suhyun Ryu),한점화(Jeom Hwa Han),한현희(Hyun Hee Han),정재훈(Jae Hoon Jeong),조정건(Jung-Gun Cho),도경란(Kyeong Ran Do) (사)한국생물환경조절학회 2018 생물환경조절학회지 Vol.27 No.3
여름철 고온으로 인해 ‘거봉’ 포도의 착색 불량이 나타나는 원인을 안토시아닌 조성의 변화로부터 구명하기 위해 본 실험을 수행하였으며, 같은 대립계 포도 품종인 ‘흑보석’의 과실 품질과 안토시아닌의 변화를 함께 비교 하였다. 착색 초기부터 30일 동안의 고온 처리에 의해 ‘거봉’과 ‘흑보석’ 모두에서 과피의 착색이 감소하였지만, ‘흑보석’은 온도 처리의 종료 이후 안토시아닌 함량이 대조구의 수준으로 증가하였고, ‘거봉’은 착색이 정지된 상태로 안토시아닌 함량이 증가하지 못했다. 고온에 의해 ‘거봉’의 안토시아니딘은 Mal, Del, Pet의 순으로 크게 감소하였으며, 개별 성분으로는 diglucoside 및 Malacylated 형태가 가장 크게 감소하였다. 안토시아닌의 형태별 함량을 비교한 결과, ‘거봉’ 과피에서 고온에 의해 acylated 형태가 non-acylated 형태에 비해서 더 크게 감소하였고, B ring의 tri-hydroxylated 형태가 di-hydroxylated 형태보다 더 큰 비율로 감소하였다. ‘거봉’에서 모든 그룹의 안토시아닌 함량이 총 안토시아닌과 비슷한 경향으로 감소하였고, ‘흑보석’에서는 모든 그룹의 합성이 고온에 의해 억제되었다가 온도 처리가 종료된 이후 대조구의 수준으로 회복되었다. 따라서 착색 초기의 고온에 의한 ‘거봉’의 착색 불량은 특정 안토시아닌의 감소에 의한 것이 아니라, 전체적인 안토시아닌의 생합성 자체가 고온에 의해 억제되었기 때문으로 판단되었다. We analyzed the skin coloration and anthocyanin composition of ‘Kyoho’ and ‘Heukboseok’ grape berries to determine the cause of poor coloring in ‘Kyoho’ berry skins under high temperature (HT) at veraison. Although the skin coloration inhibited in both ‘Kyoho’ and ‘Heukboseok’ berries under HT for 30 days from veraison, the total anthocyanin content in ‘Heukboseok’ berry skins increased to the level of control after the end of temperature treatment, but ‘Kyoho’ did not increase. Malvidin derivatives were most significantly reduced in ‘Kyoho’ berry skins, followed by those of delphinidin and petunidin. Among individual anthocyanins, diglucosides and acylated malvidin derivatives were most decreased in ‘Kyoho’ berry skins. Acylated and tri-hydroxylated anthocyanins were reduced more than those of non-acylated and dihydroxylated, respectively. All different types of anthocyanin components in ‘Kyoho’ berry skins decreased by HT, and they were similar to that of total anthocyanin. In ‘Heukboseok’ berry skins, accumulations of all different types of anthocyanins were inhibited by HT, and increased to the level of control after the end of the treatment. These results suggest that the poor coloration of ‘Kyoho’ under HT at veraison was not caused by the decrease of specific anthocyanins but because the whole anthocyanin biosynthesis was suppressed by HT.