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Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
Run-Hui Zhang,Runhao Jin,Hao Deng,Qing-Kun Shen,Zhe-Shan Quan,Chun-Mei Jin 대한기생충학열대의학회 2021 The Korean Journal of Parasitology Vol.59 No.3
Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in relieving T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent.