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Altered fast and slow inactivation of the N440K Nav1.4 mutant in a periodic paralysis syndrome
Lossin, C.,Nam, T.-S.,Shahangian, S.,Rogawski, M. A.,Choi, S.-Y.,Kim, M.-K.,Sunwoo, I.-N. Ovid Technologies (Wolters Kluwer) - American Acad 2012 Neurology Vol.79 No.10
<P>To electrophysiologically characterize the Na(v)1.4 mutant N440K found in a Korean family with a syndrome combining symptoms of paramyotonia congenita, hyperkalemic periodic paralysis, and potassium-aggravated myotonia.</P>
Gaj, Kris,Soonhak Kwon,Baier, Patrick,Kohlbrenner, Paul,Hoang Le,Khaleeluddin, Mohammed,Bachimanchi, Ramakrishna,Rogawski, Marcin IEEE 2010 IEEE Transactions on Computers Vol.59 No.9
<P>A novel portable hardware architecture of the Elliptic Curve Method of factoring, designed and optimized for application in the relation collection step of the Number Field Sieve, is described and analyzed. A comparison with an earlier proof-of-concept design by Pelzl et al. has been performed, and a substantial improvement has been demonstrated in terms of both the execution time and the area-time product. The ECM architecture has been ported across five different families of FPGA devices in order to select the family with the best performance to cost ratio. A timing comparison with the highly optimized software implementation, GMP-ECM, has been performed. Our results indicate that low-cost families of FPGAs, such as Spartan-3 and Spartan-3E, offer at least an order of magnitude improvement over the same generation of microprocessors in terms of the performance to cost ratio, without the use of embedded FPGA resources, such as embedded multipliers.</P>