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- 저자 : Rita Pagiotti (검색결과 2 건)
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Anti-Inflammatory and Analgesic Effects of Spartium junceum L. Flower Extracts: A Preliminary Study
Luigi Menghini,Paola Massarelli,Giancarlo Bruni,Rita Pagiotti 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.3
Our objective was to study the anti-inflammatory and analgesic activity of extract of Spartium junceumL.flowers. Samples of flowers were collected from wild plants, dried, powdered, and extracted with hexane and methanol. Theextracts were evaporated to dryness and then suspended in suitable solvent. They were then tested for anti-inflammatory ac-tivity in the carrageenin rat paw edema test and for analgesic activity in the Randall and Selitto mechanical pressure test andin the tail-flick test. Twenty-four hours after treatment, the gastric mucosa of each rat was observed macroscopically. Basedon these results the hexane extract was fractioned by column chromatography, and the fractions obtained were tested in thesame way. The results showed good anti-inflammatory activity only for a single fraction of the hexane extract, while all theextracts and all the other hexane fractions showed both peripheral and central analgesic activity. In rats treated with the testedcompounds hyperemia and ulcers were absent. The data from this preliminary study reveal interesting pharmacological prop-erties of S. junceumL. flowers extract related to the marked analgesic activity and the absence of gastric ulcerogenic activ-ity.
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Phytochemical Investigation on Leaf Extract of Cordia salicifolia Cham.
Luigi Menghini,Francesco Epifano,Lidia Leporini,Rita Pagiotti,Bruno Tirillini 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
The dichloromethane extract of leaves of Cordia salicifoliaCham. (Family Boraginaceae) was fractionated bySiO2 column chromatography and analyzed by gas chromatography, gas chromatography-mass spectrometry, and nuclear mag-netic resonance spectroscopy. The apolar extract is characterized by a very high content of (. )-spathulenol (0.53%). The ma-jor component of the extract exhibited a very weak activity as an inhibitor of growth of Helicobacter pylori in vitro(mini-mum inhibitory concentration. 200 .g/mL).
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