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흑색종에서 칼슘 채널 차단제에 의한 엑소좀 분비 억제를 통한 면역 관문 억제 효능 규명
라키불알람(Rakibul Alam),김종인(Jong-In Kim),이찬형(Chan-Hyeong Lee),박성식(Seong-Sik Park),백문창(Moon-Chang Baek) 대한약학회 2021 약학회지 Vol.65 No.4
Melanoma is a belligerent cutaneous malignancy. Multiple therapeutic options, including immunotherapy and targeted therapy, have shown remarkable promise in treating metastatic melanoma. Exosomes containing programmed cell death ligand 1 (PD-L1) secreted from melanoma bind to programmed cell death 1 (PD-1) on the surface of CD8+ T cells. As a result, melanoma not only evades the immune surveillance of CD8+ T cells but also inhibits their activation and facilitates the growth and proliferation of cancer cells. In this study, we identified nicardipine, an FDA-approved L-type calcium channel inhibitor, which downregulates the expression of proteins involved in exosome biogenesis and secretion as well as exosomal PD-L1 secretion, from metastatic melanoma cells. Furthermore, nicardipine suppresses PD-L1 expression after interferon-γ-mediated stimulation and enhances CD8+ cell function, similar to the function of PD-L1- blocking antibodies in cancer therapies. This could lead to the development of next-generation anticancer drugs for the treatment of metastatic melanoma.
EFFECT OF DIETARY CONCENTRATIONS OF ENERGY AND PROTEIN ON THE PERFORMANCE AND BEHAVIOR OF DUCKS
Md Rakibul Hassan,Shabia Sulatana,C. I. Lim,K. S. Ryu 한국가금학회 2016 한국가금학회 정기총회 및 학술발표회 Vol.2016 No.11
The present experiment was conducted to evaluate the effect of dietary energy and protein on the performance and behavior of ducks. A total of 600 d-old ducklings were divided into 3 × 2 factorial arrangements (4 replicate pens/treatment; 25 ducks/pen) and were assigned to the diet containing (1 –21 d, 2850, 2900 and 2950 kcal of ME/㎏ and 22–42 d, 2950, 3000 and 3050 kcal of ME/㎏) and CP (1–21 d, 21 and 22% and 22–42 d, 18 and 19%) respectively. Video was recorded twice in a day and observed 5 consecutive days per week. Duration of feeding, drinking, sitting, walking, standing, preening, wing flapping, wing stretching, tail wagging, head shaking, body shaking, ground pecking, peck object, and social interaction behavior were recorded. Ducks had ad libitum access to commercial pellet and water. Dietary interaction of 2950 ㎉/㎏ ME and 22% CP containing diet did increase weight gain at first 21d. During the 22–42 d, weight gain was increased in 3050 ㎉/㎏ ME and 18% CP containing diet (P < 0.05). Ducks fed diets with a lower energy and protein (2850×21 for 1-3 wks and 2950×18 for 4-6 wks) spent more time on feed intake and so less time is remaining for activity of ducks and thus reduced walking, ground pecking and social interaction behavior (P < 0.05). Drinking behavior was increased and ground pecking behavior was decreased with protein dependent manner (p<0.05). Increasing the energy and protein contents in the diet resulted in decreased feeding time and increased walking and ground pecking behavior of ducks. Therefore, the present results suggest that 2950 ㎉/㎏ ME and 22% CP for the starting period and 3050 ㎉/㎏ ME and 18% CP for the finishing period is effective for enhancing growth performance without any adverse effect on behavioral needs of cherry valley ducks.
A novel particle swarm optimization-based grey model for the prediction of warehouse performance
Md. Rakibul Islam,Syed Mithun Ali,Amir Mohammad Fathollahi-Fard,Golam Kabir 한국CDE학회 2021 Journal of computational design and engineering Vol.8 No.2
Warehouses constitute a key component of supply chain networks. An improvement to the operational efficiency and the productivity of warehouses is crucial for supply chain practitioners and industrial managers. Overall warehouse efficiency largely depends on synergic performance. The managers preemptively estimate the overall warehouse performance (OWP), which requires an accurate prediction of a warehouse’s key performance indicators (KPIs). This research aims to predict the KPIs of a ready-made garment (RMG) warehouse in Bangladesh with a low forecasting error in order to precisely measure OWP. Incorporating advice from experts, conducting a literature review, and accepting the limitations of data availability, this study identifies 13 KPIs. The traditional grey method (GM)—the GM (1, 1) model—is established to estimate the grey data with limited historical information but not absolute. To reduce the limitations of GM (1, 1), this paper introduces a novel particle swarm optimization (PSO)-based grey model—PSOGM (1, 1)—to predict the warehouse’s KPIs with less forecasting error. This study also uses the genetic algorithm (GA)-based grey model—GAGM (1, 1)—the discrete grey model—DGM (1, 1)—to assess the performance of the proposed model in terms of the mean absolute percentage error and other assessment metrics. The proposed model outperforms the existing grey models in projecting OWP through the forecasting of KPIs over a 5-month period. To find out the optimal parameters of the PSO and GA algorithms before combining them with the grey model, this study adopts the Taguchi design method. Finally, this study aims to help warehouse professionals make quick OWP estimations in advance to take control measures regarding warehouse productivity and efficiency.
Md. Rakibul Hassan Bulbul,Md. Atiar Rahman,Md. Zillur Rahman,Talha Bin Emran,Mirola Afroze,Mala Khan,Muhammad Abid Hasan Chowdhury,Mohammed Auwal Ibrahim,Mohammed Sohel Chowdhury 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.1
This study investigated the restorative effect of Leea macrophylla ethanol root extract (LMERE) in carbon tetrachloride (CCl4) induced hepatic injury. It also tried to unfold the underlying mechanism through ligand-receptor interactions. Prior to conduct the CCl4 induced animal model study, the in vitro antioxidative capacities of LMERE were investigated. Gas chromatography mass spectroscopy (GC–MS) was accomplished to identify the prevalent bioactive compounds. The molecular docking was performed using Schrödinger Suites 2017-1. Results showed the promising antioxidative potentials of LMERE in in vitro models. Upon treatment of CCl4 intoxicated animals with LMERE, serum ALT and AST were found to be significantly (p < 0.05) reduced compared to the CCl4 control while LMERE50 was noted as the best dose in restoring the hepatic markers. Serum lipids and total protein were significantly restored compared to control. Remarkable changes of cell necrosis, apoptosis and sinusoidal dilution were noticed in histopathological assay of liver tissue. mRNA expression for superoxide dismutase (SOD1) and catalase was multifold increased which are statistically significant compared to reference drug, silymarin. In docking study, octadecanoic acid showed the lowest binding energy and highest binding affinity with the protein (ID: 1VKX) which is a crystallized structure of NF-κB p50/p65 heterodimer involved in cytokine production. The findings demonstrate that LMERE restores the hepatic damage by the mRNA expression of antioxidative enzymes while LMERE50, at a glance, seems the most suitable dose.
Hassan, Md. Rakibul,Choe, Ho Sung,Ryu, Kyeong Seon The Korean Society of Poultry Science 2012 韓國家禽學會誌 Vol.39 No.4
This study was undertaken to investigate the influence of multi-probiotics, fermented ginseng byproducts and fermented sulfone as an alternative to probiotics on performance, intestinal microflora and immunity of broiler. A five weeks trial was conducted with one day old Ross${\times}$Ross broilers (n=340), divided into five groups which further divided into 4 replicates with 17 birds in each replicate. Birds were assigned to 5 dietary treatments as control, antibiotic avilamycin (AB), multi-probiotics (MP), fermented sulfone (FS) and fermented ginseng byproducts (FGB). Growth parameters were recorded on weekly basis while rest of the parameters viz. blood and faeces were collected at the end of the experiment. Growth parameters were not affected statistically by dietary treatments. However, numerically, higher body weight, splenocytes proliferation and lower total cholesterol and LDL values were found in MP treatment (P>0.05). Salmonella spp. count ($P{\leq}0.001$) and E. coli (P<0.001) concentrations in the ileum were found lowest in AB treatment while FS group showed lowest level of yeast (P<0.10) and Lactobacillus spp. ($P{\leq}0.001$). Fecal ammonia and $CO_2$ emission was significantly decreased in FGB than other dietary treatments (P<0.05). It was concluded that multi-probiotics would be valuable feed additives to improve the growth performance, Lactobacillus proliferation and immunity of broiler chicks.
Hassan, Md. Rakibul,Sultana, Shabiha,Choe, Ho Sung,Ryu, Kyeong Seon The Korean Society of Poultry Science 2012 韓國家禽學會誌 Vol.39 No.4
Different housing systems have considerable influence on performance in poultry production. Therefore, the present study was undertaken to investigate the impact of different housing systems on the performance, bone mineral density and egg yolk fatty acid composition in laying hen. Hy-line brown pullets (n=450) of 12 weeks age were randomly divided into 3 housing systems with 6 replicates of 25 birds in each room. A diet with 2,750 kcal/kg ME and 16.5% CP was assigned to all birds. The pullets provided free access to feed and water. Significantly (P<0.05) higher values for egg production, egg mass and feed conversion efficiency were found in battery cages, however egg weight, egg shell color and breaking strength was remarkably (P<0.05) higher in floor system. The albumin height and Haugh unit were significantly higher (P<0.05) in battery cages which was statistically similar to aviary housing system. The egg yolk fatty acids concentration of linoleic acid and linolenic acids were significantly higher in aviary and in floor system, respectively, however both values were lower in battery cages. Saturated and unsaturated fatty acid content (%) in egg yolk did not influence by any housing systems. Bone mineral density was significantly higher (P<0.05) in floor and aviary housing system than that of battery cage system. It was concluded that in battery cages the egg production and composition maximized, however higher bone mineral density and yolk fatty acids content can be improved in the laying hen reared on floor and aviary housing systems.
An Empirical Investigation on the Adoption of E-Commerce in Bangladesh
Hoque, Md. Rakibul,Ali, Mohammad Afshar,Mahfuz, Mohammad Abdullah The Korea Society of Management Information System 2015 Asia Pacific Journal of Information Systems Vol.25 No.1
Electronic Commerce or e-commerce implies such an industry where goods and services are bought and sold over electronic systems. This is rapidly growing sectors in Bangladesh which influence local and international trade. Government of Bangladesh has also initiated quite a good number of measures for the expansion of e-commerce. However, low adoption of e-commerce is not uncommon in Bangladesh. The objective of this study is to determine the factors that influence the adoption of e-commerce services in Bangladesh. Extended version of Technology Acceptance Model (TAM) is envisaged as the theoretical backbone of the study. Reliability analysis using Cronbach's Alpha test indicates that the research model is internally consistent. The study reveals that 35 percent of respondents became interested in e-commerce services from advertisement on Internet or other electronic media. The findings of the study shows that all the four constructs, namely-Computer Self Efficacy, Perceived Credibility, Perceived Usefulness and Perceived Ease of Use have significant effect on the adoption of e-commerce. The study has also demonstrated that Perceived Usefulness appeared as the most important factor in describing user's adoption of e-commerce.