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- 저자 : Puripattanavong, Jindaporn (검색결과 2 건)
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Antityrosinase and antimicrobial activities from Thai medicinal plants
Dej-adisai, Sukanya,Meechai, Imron,Puripattanavong, Jindaporn,Kummee, Sopa 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4
Various dermatological disorders and microbial skin infection can cause hyperpigmentation. Therefore, screenings for whitening and antimicrobial agents from Thai medicinal plants have been of research interest. Seventy-seven ethanol plant extracts were investigated for antityrosinase activity, eleven samples showed the tyrosinase inhibition more than 50 % were further preliminary screening for antimicrobial activity by agar disc diffusion and broth micro-dilution methods. Artocarpus integer (Thunb.) Merr. (Moraceae) root extract, which showed the potential of tyrosinase inhibition with $90.57{\pm}2.93%$ and antimicrobial activity against Staphylococcus aureus, S. epidermidis, Propionibacterium acnes and Trichophyton mentagophytes with inhibition zone as $9.10{\pm}0.00$, $10.67{\pm}0.09$, $15.25{\pm}0.05$ and $6.60{\pm}0.17mm$, respectively was selected for phytochemical investigation. Three pure compounds were isolated as artocarpin, cudraflavone C and artocarpanone. And artocarpanone exhibited antityrosinase effect; artocarpin and cudraflavone C also showed the potential of antibacterial activity against S. aureus, S. epidermidis and P. acnes with MIC at 2, 4 and $2{\mu}g/ml$, respectively and MBC at $32{\mu}g/ml$ for these bacteria. So, these pure compounds are interesting for further study in order to provide possibilities of new whitening and antibacterial development. This will be the first report of phytochemical investigation of A. integer root.
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Antityrosinase and antimicrobial activities from Thai medicinal plants
Sukanya Dej-adisai,Imron Meechai,Jindaporn Puripattanavong,Sopa Kummee 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4
Various dermatological disorders and microbialskin infection can cause hyperpigmentation. Therefore,screenings for whitening and antimicrobial agents fromThai medicinal plants have been of research interest. Seventy-seven ethanol plant extracts were investigated for antityrosinaseactivity, eleven samples showed the tyrosinaseinhibition more than 50 % were further preliminaryscreening for antimicrobial activity by agar disc diffusionand broth micro-dilution methods. Artocarpus integer(Thunb.) Merr. (Moraceae) root extract, which showed thepotential of tyrosinase inhibition with 90.57 ± 2.93 %and antimicrobial activity against Staphylococcus aureus,S. epidermidis, Propionibacterium acnes and Trichophytonmentagophytes with inhibition zone as 9.10 ± 0.00,10.67 ± 0.09, 15.25 ± 0.05 and 6.60 ± 0.17 mm, respectivelywas selected for phytochemical investigation. Threepure compounds were isolated as artocarpin, cudraflavoneC and artocarpanone. And artocarpanone exhibited antityrosinaseeffect; artocarpin and cudraflavone C alsoshowed the potential of antibacterial activity againstS. aureus, S. epidermidis and P. acnes with MIC at 2, 4 and2 lg/ml, respectively and MBC at 32 lg/ml for these bacteria. So, these pure compounds are interesting for furtherstudy in order to provide possibilities of new whitening andantibacterial development. This will be the first report ofphytochemical investigation of A. integer root.
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