Heat Transfer of Two-Phase Flow in a Heated Capillary

Y. P. Peles,L. P. Yarin,G. Hetsroni 대한기계학회 1998 Heat transter conference Vol.2 No.1

Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2<i>/Caspr2</i> knockout neurons

Varea, Olga,Martin-de-Saavedra, Maria Dolores,Kopeikina, Katherine J.,Schü,rmann, Britta,Fleming, Hunter J.,Fawcett-Patel, Jessica M.,Bach, Anthony,Jang, Seil,Peles, Elior,Kim, Eunjoon,Penzes, P National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.19

<P><B>Significance</B></P><P>In this paper, we characterize, for the first time to our knowledge, synaptic phenotypes in contactin associated protein-like 2 (<I>Cntnap2</I>) knockout neurons and reveal a novel role for CNTNAP2 in the correct trafficking of AMPA-type glutamate receptors. In addition, we report that cellular phenotypes emerge late in postnatal development, suggesting a mechanism for the apparent late emergence of some <I>CNTNAP2</I>-associated disorders. Taken together, our findings may provide insight into the mechanism underlying pathogenesis of <I>CNTNAP2</I>-associated neuropsychiatric disorders.</P><P>Central glutamatergic synapses and the molecular pathways that control them are emerging as common substrates in the pathogenesis of mental disorders. Genetic variation in the contactin associated protein-like 2 (<I>CNTNAP2</I>) gene, including copy number variations, exon deletions, truncations, single nucleotide variants, and polymorphisms have been associated with intellectual disability, epilepsy, schizophrenia, language disorders, and autism. CNTNAP2, encoded by <I>Cntnap2</I>, is required for dendritic spine development and its absence causes disease-related phenotypes in mice. However, the mechanisms whereby CNTNAP2 regulates glutamatergic synapses are not known, and cellular phenotypes have not been investigated in <I>Cntnap2</I> knockout neurons. Here we show that CNTNAP2 is present in dendritic spines, as well as axons and soma. Structured illumination superresolution microscopy reveals closer proximity to excitatory, rather than inhibitory synaptic markers. CNTNAP2 does not promote the formation of synapses and cultured neurons from <I>Cntnap2</I> knockout mice do not show early defects in axon and dendrite outgrowth, suggesting that CNTNAP2 is not required at this stage. However, mature neurons from knockout mice show reduced spine density and levels of GluA1 subunits of AMPA receptors in spines. Unexpectedly, knockout neurons show large cytoplasmic aggregates of GluA1. Here we characterize, for the first time to our knowledge, synaptic phenotypes in <I>Cntnap2</I> knockout neurons and reveal a novel role for CNTNAP2 in GluA1 trafficking. Taken together, our findings provide insight into the biological roles of CNTNAP2 and into the pathogenesis of <I>CNTNAP2</I>-associated neuropsychiatric disorders.</P>

Parents Involvement Inventory: Based on the WhatsApp Application (PIWI)

Daniel Peled,Elaine Hoter,Emanuel Tamir The Pacific Early Childhood Education Research Ass 2021 Asia-Pacific journal of research in early childhoo Vol.15 No.3

Today many parents and preschool teachers communicate through social media. The purpose of this pilot study is to develop a tool that can reflect the new reality of parental involvement. The Parents Involvement WhatsApp Inventory (PIWI) was developed through a questionnaire given to 324 preschool teachers in different areas in Israel. The questionnaire incorporated three perspectives: cognitive, attitudinal (emotional) and informative. Five categories were identified and validated by factor analysis representing 41 out of the 55 items: satisfaction, safety network, media usage, limitations, and decision making. The main implications of the research are the contribution of this new tool to understand contemporary parental involvement and to provide an up-to-date tool to measure this involvement. Further research is required to validate the tool in different educational frameworks.

Rethinking the China-Israel BIT in Light of the Fragmented International Investment Legal Order: A Commentary

Hadas Peled 이준국제법연구원 2016 China and WTO Review Vol.2 No.2

Video Quality Representation Classification of Encrypted HTTP Adaptive Video Streaming

( Ran Dubin ),( Ofer Hadar ),( Amit Dvir ),( Ofir Pele ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.8

The increasing popularity of HTTP adaptive video streaming services has dramatically increased bandwidth requirements on operator networks, which attempt to shape their traffic through Deep Packet inspection (DPI). However, Google and certain content providers have started to encrypt their video services. As a result, operators often encounter difficulties in shaping their encrypted video traffic via DPI. This highlights the need for new traffic classification methods for encrypted HTTP adaptive video streaming to enable smart traffic shaping. These new methods will have to effectively estimate the quality representation layer and playout buffer. We present a new machine learning method and show for the first time that video quality representation classification for (YouTube) encrypted HTTP adaptive streaming is possible. The crawler codes and the datasets are provided in [43,44,51]. An extensive empirical evaluation shows that our method is able to independently classify every video segment into one of the quality representation layers with 97% accuracy if the browser is Safari with a Flash Player and 77% accuracy if the browser is Chrome, Explorer, Firefox or Safari with an HTML5 player.

Experimental characterization of the self-healing capacity of cement based materials and its effects on the material performance: A state of the art report by COST Action SARCOS WG2

Ferrara, Liberato,Van Mullem, Tim,Alonso, Maria Cruz,Antonaci, Paola,Borg, Ruben Paul,Cuenca, Estefania,Jefferson, Anthony,Ng, Pui-Lam,Peled, Alva,Roig-Flores, Marta,Sanchez, Mercedes,Schroefl, Christ Elsevier 2018 Construction and Building Materials Vol.167 No.-

<P><B>Abstract</B></P> <P>Heuristically known at least since the first half of XIX century, the self-healing capacity of cement-based materials has been receiving keen attention from the civil engineering community worldwide in the last decade. As a matter of fact, stimulating and/or engineering the aforementioned functionality via tailored addition and technologies, in order to make it more reliable in an engineering perspective, has been regarded as a viable pathway to enhance the durability of reinforced concrete structures and contribute to increase their service life.</P> <P>Research activities have provided enlightening contributions to understanding the mechanisms of crack self-sealing and healing and have led to the blooming of a number of self-healing stimulating and engineering technologies, whose effectiveness has been soundly proved in the laboratory and, in a few cases, also scaled up to field applications, with ongoing performance monitoring. Nonetheless, the large variety of methodologies employed to assess the effectiveness of the developed self-healing technologies makes it necessary to provide a unified, if not standardized, framework for the validation and comparative evaluation of the same self-healing technologies as above. This is also instrumental to pave the way towards a consistent incorporation of self-healing concepts into structural design and life cycles analysis codified approaches, which can only promote the diffusion of feasible and reliable self-healing technologies into the construction market.</P> <P>In this framework the Working Group 2 of the COST Action CA 15202 “Self-healing as preventive repair of concrete structures – SARCOS” has undertaken the ambitious task reported in this paper. As a matter of fact this state of the art provides a comprehensive and critical review of the experimental methods and techniques, which have been employed to characterize and quantify the self-sealing and/or self-healing capacity of cement-based materials, as well as the effectiveness of the different self-sealing and/or self-healing engineering techniques, together with the methods for the analysis of the chemical composition and intrinsic nature of the self-healing products. The review will also address the correlation, which can be established between crack closure and the recovery of physical/mechanical properties, as measured by means of the different reviewed tests.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Review of test methods for assessing healing efficiency. </LI> <LI> Novel perspective in correlating healing to durability and mechanical recovery. </LI> <LI> Correlation between different test methods. </LI> <LI> Characterization methods of healing products. </LI> <LI> Pioneer monitored case studies are presented. </LI> </UL> </P>