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RISS 인기검색어
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- 저자 : Patrícia M. Brossi (검색결과 1 건)
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Autologous processed plasma: cytokine profile and effects upon injection into healthy equine joints
Juliana J. Moreira,Ana Paula L. Moraes,Patrícia M. Brossi,Thaís S.L. Machado,Yara M. Michelacci,Cristina O. Massoco,Raquel Y.A. Baccarin 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.1
This experimental controlled study was performed to evaluate the composition of autologous processed plasma (APP), and the effects of APPintra-articular injection into healthy equine metacarpophalangeal joints. The effects on joints were analysed with a short-phase protocol anda prolonged-phase protocol using saline-injected joints as controls. For the short protocol, horses received one intra-articular APP injection. Synovial fluid samples were collected prior to the injection and 3, 6, 24, 48, and 16 h after treatment. For the prolonged protocol, the jointsreceived three weekly injections of APP, and samples were collected at 0, 7, 14, 21, and 28 days before APP administration. IL1-ra level wasfound to be increased in APP compared to plasma. Upon intra-articular administration of APP, transient (up to 24 h) increases in white bloodcell (WBC) counts along with elevated protein and prostaglandin E2 (PGE2) concentrations were observed in the treated joints. Over the 28-dayobservation period, APP did not elicit changes relative to baseline levels, but WBC counts, PGE2 and chondroitin sulphate concentrationswere lower than those found in the control. In conclusion, APP intra-articular injection induced a mild and transitory inflammatory responsebut no inflammation reaction was observed over a longer period of treatment and observation.
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