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최길순,신유섭,김주희,최선윤,이수걸,남영희,이영목,박해심,PRANA Study Group 대한의학회 2014 Journal of Korean medical science Vol.12 No.12
Depression is an important comorbidity of asthma. However, little information is availableabout depression and its potential impact on asthma control in Korean adult asthmapatients. We aimed to estimate the prevalence and risk factors for depression in Koreanadults with persistent asthma. The 127 non-elderly (20-64 yr) and 75 elderly ( ≥ 65 yr)patients with asthma were recruited. Demographic and clinical data were extracted, andthe patients completed the Asthma Specific Quality of Life (AQOL) questionnaire andasthma control test (ACT). Depression status was defined using the Korean version of thePatient Health Questionnaire-9 (PHQ-9). Depression was more prevalent in non-elderly(18.9%) than in elderly patients with asthma (13.3%). Patients with depression weresignificantly younger, had lower economic status, shorter disease duration, poorer asthmacontrol, and worse AQOL scores (P < 0.05). Within the non-elderly group, younger ageand shorter disease duration were significantly associated with depression (P < 0.05). Within the elderly group, a higher body mass index and current smoking status weresignificantly associated with depression (P < 0.05). The PHQ-9 score was significantlycorrelated with worse ACT and AQOL scores in both groups. In conclusion, depression isstrongly associated with poor asthma control and quality of life in Korean adult asthmapatients. Our results provide important clues that used to target modifiable factors whichcontribute to development of depression in asthma patients.