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- 저자 : Orhan Halil İbrahim (검색결과 2 건)
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Maulana and sekanjabin (oxymel): a ceremonial relationship with gastronomic and health perspectives
Orhan Halil İbrahim,Yılmaz İlkay,Tekiner İsmail Hakkı 한국식품연구원 2022 Journal of Ethnic Foods Vol.9 No.-
Sekanjabin , also known as Oxymel , is an ancient beverage including honey, fermented vinegar, water, and various fruits and herbs. Great physicians Hippocrates, Galen, and Avicenna recommended treating gastrointestinal disorders, pain, asthma, thoracic, cough, sore throat, foul, and breath. Furthermore, Maulana, a symbol of tolerance that is humanism-flexible and non-violent, frequently mentions this beverage in his great masterpieces “ Divan-ı Kebir ” and “ Masnavi .” Therefore, it can be evaluated as an intangible cultural heritage of Western and near Asian civilizations and has a significant and ceremonial role in Maulana and Maulawi Culture. From a gastronomic and health perspective, this study explored the ceremonial relationship between Maulana and sekanjabin.
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Özden Eyyüp Sabri,Aşcı Halil,Büyükbayram Halil İbrahim,Sevük Mehmet Abdulkadir,İmeci Orhan Berk,Doğan Hatice Kübra,Özmen Özlem 대한마취통증의학회 2023 Korean Journal of Anesthesiology Vol.76 No.5
Background: Acute kidney injury (AKI) is a serious pathology that causes dysfunction in concentrating urine due to kidney damage, resulting in blood pressure dysregulation and increased levels of toxic metabolites. Dexpanthenol (DEX), a pantothenic acid analog, exhibits anti-inflammatory and anti-apoptotic properties in various tissues. This study investigated the protective effects of DEX against systemic inflammation-induced AKI. Methods: Thirty-two female rats were randomly assigned to the control, lipopolysaccharide (LPS), LPS+DEX, and DEX groups. LPS (5 mg/kg, single dose on the third day, 6 h before sacrifice) and DEX (500 mg/kg/d for 3 d) were administered intraperitoneally. After sacrifice, blood samples and kidney tissues were collected. Hematoxylin and eosin, caspase-3 (Cas-3), and tumor necrosis factor alpha (TNF-α) staining were performed on the kidney tissues. The total oxidant status (TOS) and total antioxidant status were measured using spectrophotometric methods. Aquaporin-2 (AQP-2), silent information regulator 1 (SIRT1), and interleukin-6 (IL-6) were detected using quantitative reverse transcription-polymerase chain reaction analysis.Results: Histopathological analysis revealed that DEX treatment ameliorated histopathological changes. In the LPS group, an increase in the blood urea nitrogen, creatinine, urea, IL-6, Cas-3, TNF-α, and TOS levels and oxidative stress index was observed compared with the control group, whereas AQP-2 and SIRT1 levels decreased. DEX treatment reversed these effects. Conclusions: DEX was found to effectively prevent inflammation, oxidative stress, and apoptosis in the kidneys via the SIRT1 signaling pathway. These protective properties suggest DEX’s potential as a therapeutic agent for the treatment of kidney pathologies.
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