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- 저자 : Olusola O. Elekofehinti (검색결과 2 건)
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Olusola Olalekan Elekofehinti,Jean Paul Kamdem,Daiane Francine Meinerz,Ige Joseph Kade,Isaac Gbadura Adanlawo,Joa˜o Batista Teixeira Rocha 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9
Solanum anguivi fruit saponin has antidiabeticproperty via interference with cellular energy metabolismand inhibition of reactive oxygen species (ROS) generation. In the current study, brain specific in vitro anti-oxidantrole of S. anguivi saponin was investigated in the P2synaptosomal fraction of rat brain. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reductionassay, S. anguivi saponin concentration- dependently(10–200 lg/ml) reversed Fe2? and sodium nitroprussideinduceddecrease in mitochondrial activity via inhibition ofROS production, ROS-induced oxidation of protein andnon-protein thiol-containing molecules and lipid peroxidationas measured by thiobarbituric acid reactive substanceslevels. Conclusively, S. anguivi fruit saponin represents a class of natural compounds with the ability toreverse synaptosomal disruption, loss of mitochondrialintegrity and function often associated with the progressionof Huntington’s disease, Alzheimer disease, Parkinsondisease and amyotrophic lateral sclerosis diseases.
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Merit E. Ayevbuomwan,Olusola O. Elekofehinti,Francis A. Obuseh,Ehimwenma S. Omoregie 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.4
Detarium microcarpum is a legume tree of tropical Africa, widely known for its ethno-medicinal potentials. Previous studies have reported its rich contents of phytochemicals which could be linked to the bioactive principle of the plant. The in vitro antisickling properties of D. microcarpum stem bark was evaluated using blood samples obtained from thirty-fve confrmed sickle cell disease patients using standard microscopic techniques. The research outcome showed that D. microcarpum extract inhibited sickling of red blood cells with a laudable mean diference compared to p-hydrozybenzoic acid (reference antisickling drug) which is a pure compound. To further expounds it’s mechanism of action, six compounds previously isolated from D. microcarpum stem bark and fruits was docked into the active sites of deoxy-hemoglobin (PDB ID: IGZX) and 2, 3-bisphosphoglycerate mutase (PDB ID: 1T8P) using Autodock Vina algorithm. Results from the in silico studies showed that oxokolavenic acid, 5α, 8α -2-oxokalavenic acid and Copalic acid exhibited the most favorable ligand–protein molecular interaction with deoxy-hemoglobin and 2,3-bisphosphoglycerate mutase when compared with the reference antisickling drug, hydroxyurea. The interaction of these compounds with deoxy-hemoglobin could alter hemoglobin conformation, favoring the relaxed state, thereby delaying/inhibiting hemoglobin polymerization and sickling. Their interactions with 2, 3-bisphosphoglycerate mutase could inhibit 2, 3-bisphosphoglycerate synthesis, thus delaying enhanced delivery of oxygen to tissues which is twice the case seen in sickle cell anemia. This clearly shows the possible mechanism of action of D. microcarpum and further substantiates the antisickling potential of these compounds derived from D. microcarpum leaves and fruits.
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