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- 저자 : Oleksiy Selesnov (검색결과 1 건)
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Oksana Sulaieva,Olena Chernenko,Oleksiy Selesnov,Oleksandr Nechay,Oleksandr Maievskyi,Tetyana Falalyeyeva,Nazarii Kobyliak,Olena Tsyryuk,Yurii Penchuk,Dmytro Shapochka 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.2
Background: The relationship between Hashimoto thyroiditis (HT) and papillary thyroid carcinoma (PTC) remains uncertain. Weassessed the impact of HT on the tumor immune microenvironment (TIME) in PTC. Methods: Thirty patients with PTC (group 1) and 30 patients with PTC and HT (group 2) were enrolled in this pilot study. The distribution and number of CD8+ lymphocytes, plasma cells (CD138+), regulatory T cells (forkhead box P3 [FOXP3+)], mast celltryptase (MCT+), and M2 macrophages (CD163+) were evaluated. To test the hypothesis that HT impacts PTC development viasignal transducer and activator of transcription 6 (STAT6) activation and M2 macrophage polarization, we investigated STAT6 expression in tumor and stromal cells. We also evaluated vascular endothelial growth factor (VEGF) expression by lymph node metastasis (LNM) status. Results: TIME showed significant between-group differences. Group 1 patients demonstrated immune desert or immune-excludedimmunophenotypes, while an inflamed phenotype with more CD8+ cells (P<0.001) predominated in group 2. Immune-excludedTIME was associated with the highest LNM rate. In PTC, LNM was associated with more numerous CD163+ cells. Moreover,LNM in group 1 was associated with increased numbers of mast cells peritumorally and FOXP3+ cells intratumorally and peritumorally. Group 2 demonstrated higher STAT6 but not higher VEGF expression in tumor cells. High VEGF expression was associated with LNM regardless of HT status. Conclusion: Concomitant HT impacted PTC signaling via STAT6 and TIME by increasing the number of CD8+ cells. LNM is associated with increases in CD163+ cells and VEGF expression in PTC, whereas HT affected LNM through different mechanisms.
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