http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Nydia Ávila-Vanzzini,Juan Francisco Fritche-Salazar,Nelva Marina Vázquez-Castro,Pedro Rivera-Lara,Oscar Pérez-Méndez,Humberto Martínez-Herrera,Mario Gómez-Sánchez,Alberto Aranda-Frausto,Héctor Herrera 한국심초음파학회 2016 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.24 No.4
Background: Severe aortic stenosis (AS), leads to pathological left ventricular remodeling that may worsen with concomitantoverweight and obesity (OW/O). Methods: We aimed to prospectively analyze the impact of OW/O on ventricular remodeling in severe AS, by evaluating thepercentage of intraendomyocardial fibrosis (PIEF) and the percentage of infiltrating intraendocardial lipid vacuoles (PIELV) andits relationship to global longitudinal strain (GLS) in patients with OW/O. Results: 44 patients with severe AS were included, 13 non-obese (29%) and 31 OW/O (71%), all of them with left ventricularejection fraction ≥ 55%. GLS was evaluated with 2D speckle tracking. During valve replacement, an endocardial biopsy wasobtained, where PIEF and PIELV were analyzed. Patients with higher PIEF and PIELV had greater body mass index (p < 0.0001)and worse GLS (p < 0.0053). A GLS cut-off point < -14% had a sensitivity of 75%, and a specificity of 92.8% to detect importantPIEF (AUC: 0.928, 95% confidence interval: 0.798–1.00). On multivariate analysis, OW/O and PIELV were independentlyassociated to the PIEF, and OW/O and PIEF were independently associated to GLS. A high correlation between the amount ofPIELV and PIEF were found. Conclusion: Patients with severe AS and OW/O have greater PIEF and PIELV, suggesting more pathological remodeling. GLS is useful to detect subclinical myocardial injury and is potentially useful for endomyocardial fibrosis detection. The presenceof higher PIELF may be a trigger factor for the development of intraendomyocardial fibrosis.
Excessive Weight and Obesity Are Associated to Intra-Ventricular Asynchrony: Pilot Study
Nydia Ávila-Vanzzini,Cyntia Zulema Machain Leyva,Luis Eduardo Rodríguez Castellanos,José Antonio Arias Godínez,María Eugenia Ruiz Esparza,Hector Herrera Bello 한국심초음파학회 2015 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.23 No.2
Background: Excessive weight and obesity (EwO) are independent factors in the development of heart failure; they lead toa state of myocardiopathy via inflammatory and hormonal mechanisms. If excessively accumulated, epicardial fat favors a proinflammatorystate. Ventricular asynchrony is a marker of heart failure progression and has been poorly studied in EwO. Theobjective was evaluate the relation between epicardial fat, body mass index (BMI) and mechanical synchrony measured byechocardiography, in healthy individuals with EwO. Methods: We included 55 healthy individuals between the ages of 18 and 35, 17 had a BMI < 25 kg/m2 (30.9%) and 38 had aBMI > 25 kg/m2 (EwO group) (69.09%), anthropometric measurements, transthoracic echocardiogram and synchrony evaluationwere obtained. Results: Left atrial volume, telediastolic and telesystolic left ventricular volumes and the baseline volume of the right ventriclewere greater in the EwO group (20 mL/m2 vs. 15 mL/m2, p = 0.001; 106 mL vs. 82 mL, p = 0.0149 vs. 32 mL, p = 0.001 and34 mm vs. 31 mm, p = 0.02, respectively). The Yu index also correlated with epicardial fat, r = 0.53, p < 0.01, whereby thegreater the amount of epicardial fat, the greater the dispersion timing of ventricular activation. The systolic synchrony index alsocorrelated with the BMI, p = 0.01. Conclusion: Mechanical intraventricular asynchrony is associated to EwO and the amount of epicardial fat; hence, asynchronymay be one more factor leading to heart failure in EwO individuals.