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Excessive Weight and Obesity Are Associated to Intra-Ventricular Asynchrony: Pilot Study
Nydia Ávila-Vanzzini,Cyntia Zulema Machain Leyva,Luis Eduardo Rodríguez Castellanos,José Antonio Arias Godínez,María Eugenia Ruiz Esparza,Hector Herrera Bello 한국심초음파학회 2015 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.23 No.2
Background: Excessive weight and obesity (EwO) are independent factors in the development of heart failure; they lead toa state of myocardiopathy via inflammatory and hormonal mechanisms. If excessively accumulated, epicardial fat favors a proinflammatorystate. Ventricular asynchrony is a marker of heart failure progression and has been poorly studied in EwO. Theobjective was evaluate the relation between epicardial fat, body mass index (BMI) and mechanical synchrony measured byechocardiography, in healthy individuals with EwO. Methods: We included 55 healthy individuals between the ages of 18 and 35, 17 had a BMI < 25 kg/m2 (30.9%) and 38 had aBMI > 25 kg/m2 (EwO group) (69.09%), anthropometric measurements, transthoracic echocardiogram and synchrony evaluationwere obtained. Results: Left atrial volume, telediastolic and telesystolic left ventricular volumes and the baseline volume of the right ventriclewere greater in the EwO group (20 mL/m2 vs. 15 mL/m2, p = 0.001; 106 mL vs. 82 mL, p = 0.0149 vs. 32 mL, p = 0.001 and34 mm vs. 31 mm, p = 0.02, respectively). The Yu index also correlated with epicardial fat, r = 0.53, p < 0.01, whereby thegreater the amount of epicardial fat, the greater the dispersion timing of ventricular activation. The systolic synchrony index alsocorrelated with the BMI, p = 0.01. Conclusion: Mechanical intraventricular asynchrony is associated to EwO and the amount of epicardial fat; hence, asynchronymay be one more factor leading to heart failure in EwO individuals.